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Título del libro: Autophagy In Health And Disease
Título del capítulo: Targeting autophagy: Lifestyle and pharmacological approaches

Autores UNAM:
TANIA GOMEZ SIERRA; ELENA MARTINEZ KLIMOVA; JOSE PEDRAZA CHAVERRI;
Autores externos:

Idioma:

Año de publicación:
2021
Palabras clave:

Aging; Autophagy; Bioactive compounds; Caloric restriction; Cargo; Cell fate; Chronic diseases; Exercise; MTOR; Rapamycin; Therapeutic approaches


Resumen:

Autophagy is a process by which cellular contents can be removed for degradation in the lysosome. Even though autophagy is active under basal conditions, several factors such as starvation, exercise, cytotoxins, inflammatory processes, hypoxia, oxidative stress, radiation, and amino acid deprivation can increase autophagic flux. Autophagy removes damaged or unneeded cellular components and plays a critical role in the adaptation of organisms to different stress conditions, often determining whether a cell survives or dies. Autophagy can be altered by lifestyle choices such as physical activity or feeding and fasting conditions. Autophagy can also be manipulated using pharmaceuticals or bioactive compounds to modulate the double-edged sword of autophagy in disease settings. Here, we provide an overview of mechanisms regulating autophagy as the context to understand interventional strategies. Autophagy flux is often controlled through posttranslational modification of the proteins involved and changes in complex formation. Knowledge of how compounds impact these processes under specific conditions may aid in developing innovative and targeted therapies to improve health and life span. © 2022 Elsevier Inc. All rights reserved.


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