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Título del libro: Circadian Rhythms And Their Importance
Título del capítulo: INSIGHTS INTO CIRCADIAN MODULATION OF INNATE IMMUNITY: THE ROLE OF MELATONIN AND PROENKEPHALIN-DERIVED OPIOID PEPTIDES

Autores UNAM:
HECTOR SOLIS CHAGOYAN; EDGAR FLORES SOTO; LUIS MANUEL MONTAÑO RAMIREZ; MARIA EUGENIA BETINA SOMMER CERVANTES; GERMAN OCTAVIO LOPEZ RIQUELME; RAMON ALVARADO ALVAREZ;

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Autores externos:

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Idioma:

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Año de publicación:
2022

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Palabras clave:

Adaptive immunity; Circadian rhythms; Cytokines; Enkephalin; Innate immunity; Macrophages; Melatonin

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Resumen:

The environmental day-night cycle is a condition imposed to all living beings on Earth. Through evolution both anatomy and physiology have adapted to this cycle by development of circadian rhythms. Additionally, as a process of vital importance, innate immunity should be optimum and thus, it is subject to tight regulation, including circadian modulation. Although there is evidence of circadian oscillations in diverse immune parameters, most of the underlying mechanisms and the role of the biochemical mediators involved in them have not been completely elucidated. Among biomolecules that could influence immune physiology, melatonin and proenkephalin-derived opioid peptides have been described as modulators of innate immunity. Both mediators can be synthesized in the central nervous system, as well as in peripheral organs following a nocturnal circadian rhythm. Melatonin and Met-Enkephalin (MEnk) rhythms are blunted by exposure to experimental constant light (LL). Apparently, melatonin induces the MEnk-containing peptides synthesis and release, and these opioid peptides are key factors for the action of macrophages. Interestingly, LL disrupts the circadian systems and impairs the innate immune response. Moreover, LL ablated the synthesis of MEnk-containing peptides in splenic macrophages and exogenous melatonin ameliorated the peptides release. Since macrophage functions are crucial to innate-to-adaptive transition of immune responses, the impaired enkephalins production in LL could reveal a novel role of these bioactive peptides as key circadian immunomodulatory effectors. Also, the consequences of the presence of light at night on the immune and circadian systems can be further studied to design strategies to counteract the impact of these environmental alterations on health. © 2022 by Nova Science Publishers, Inc.

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Entidades citadas de la UNAM:

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Fuente:


ISBN:
9781685075859
Editorial:
Nova Science Publishers, Inc. Nombre de la publicación:
INSIGHTS INTO CIRCADIAN MODULATION OF INNATE IMMUNITY: THE ROLE OF MELATONIN AND PROENKEPHALIN-DERIVED OPIOID PEPTIDES
Página inicial:
233
Página final:
278

Tipo de producto:
Capítulo de un Libro