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Título del libro: Clinical Bioenergetics: From Pathophysiology To Clinical Translation
Título del capítulo: Mitochondrial role in NAFLD as a chronic disease

Autores UNAM:
NORBERTO CARLOS CHAVEZ TAPIA;
Autores externos:
Idioma:
Año de publicación:
2020
Palabras clave:

Antioxidants; Lipotoxicity; Mitochondrial dynamics; Oxidative stress; Steatosis

Resumen:

Under normal conditions, the liver performs a balance between lipogenesis and lipid degradation; however, lipid homeostasis is altered in hepatic steatosis, with fatty acids and triglycerides excess, which are stored inside the hepatocyte in the form of lipid vesicles. Mitochondria play an essential role in the oxidative metabolism of biomolecules and the maintenance of liver function; therefore, alterations in their function and structure generate oxidative stress that leads to different signaling pathways dysfunction, which contributes to nonalcoholic fatty liver disease development. Mitochondrial dynamics is responsible for regulating the proper functioning of mitochondria, both in physiological processes and in pathological conditions; it includes processes such as fusion, fission, biogenesis, mitophagy, and motility throughout the cell. On the other hand, autophagy is a cellular degradation pathway that maintains cell homeostasis and provides substrates for energy generation. Consequently, it is suggested that mitochondria may be the origin of injury fate. © 2021 Elsevier Inc. All rights reserved.

Entidades citadas de la UNAM:
Fuente:


ISBN:
9780128196212
Editorial:
Elsevier Nombre de la publicación:
Mitochondrial role in NAFLD as a chronic disease
Página inicial:
155
Página final:
167

Tipo de producto:
Capítulo de un Libro



DOI:
10.1016/B978-0-12-819621-2.00006-1