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Título del libro: Alzheimer's Disease And Air Pollution: The Development And Progression Of A Fatal Disease From Childhood And The Opportunities For Early Prevention
Título del capítulo: Environmental nanoparticles, SARS-CoV-2 brain involvement, and potential acceleration of Alzheimer's and parkinson's diseases in young urbanites exposed to air pollution

Autores UNAM:
RICARDO TORRES JARDON; MARICELA OLIVIA FRANCO LIRA;

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Autores externos:

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Idioma:

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Año de publicación:
2021

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Palabras clave:

ACE2; Air pollution; Alzheimer's disease; COVID 19; Depression; Nanoparticles; Neurotropism; Parkinson's disease; SARS-CoV-2; Suicide

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Resumen:

Alzheimer's and Parkinson's diseases (AD, PD) have a pediatric and young adult onset in Metropolitan Mexico City (MMC). The SARS-CoV-2 neurotropic RNA virus is triggering neurological complications and deep concern regarding acceleration of neuroinflammatory and neurodegenerative processes already in progress. This review, based on our MMC experience, will discuss two major issues: 1) why residents chronically exposed to air pollution are likely to be more susceptible to SARS-CoV-2 systemic and brain effects and 2) why young people with AD and PD already in progress will accelerate neurodegenerative processes. Secondary mental consequences of social distancing and isolation, fear, financial insecurity, violence, poor health support, and lack of understanding of the complex crisis are expected inMMCresidents infected or free of SARS-CoV-2. MMC residents with pre-SARS-CoV-2 accumulation of misfolded proteins diagnostic of AD and PD and metal-rich, magnetic nanoparticles damaging key neural organelles are an ideal host for neurotropic SARS-CoV-2 RNA virus invading the body through the same portals damaged by nanoparticles: nasal olfactory epithelium, the gastrointestinal tract, and the alveolar-capillary portal. We urgently need MMC multicenter retrospective-prospective neurological and psychiatric population follow-up and intervention strategies in place in case of acceleration of neurodegenerative processes, increased risk of suicide, and mental disease worsening. Identification of vulnerable populations and continuous effort to lower air pollution ought to be critical steps. © 2021 The authors and IOS Press.

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Entidades citadas de la UNAM:

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Fuente:



ISBN:
9781643681597
Editorial:
IOS Press Nombre de la publicación:
Environmental nanoparticles, SARS-CoV-2 brain involvement, and potential acceleration of Alzheimer's and parkinson's diseases in young urbanites exposed to air pollution
Página inicial:
567
Página final:
591

Tipo de producto:
Capítulo de un Libro

DOI:
10.3233/AIAD210046