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Título del libro: Advances In Chemistry Research
Título del capítulo: Fatty acid ethyl esters as biomarkers of alcohol consumption

Autores UNAM:

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Autores externos:

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Idioma:

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Año de publicación:
2018

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Palabras clave:

Biomarkers; Esters; Ethanol; Phospholipids; Tissue; Alcohol consumption; Biological specimens; Biotransformation product; Fatty acid ethyl ester; Fatty acid ethyl ester (FAEEs); Linear structures; Mechanisms of formation; Toxicological analysis; Fatty acids

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Resumen:

Fatty acid ethyl esters (FAEEs) are formed through the reaction of ethanol with endogenous free fatty acids, triglycerides, lipoproteins or phospholipids, catalysed by cytosolic and microsomal FAEE synthases as well as by unspecific enzymes. Since the 1960s, these compounds have been known as biotransformation products of ethanol, and in the 1990s they were proposed as promising biomarkers for monitoring ethanol exposure. Indeed, they present a linear structure which contains the intact ethyl group of ethanol, which translates into biomarkers with high specificity and sensitivity towards alcohol consumption since it excludes other reasons than alcohol consumption for their formation. The FAEEs include over 20 species, while not all the species are used as alcohol biomarkers, several species have been successfully applied as alcohol biomarkers in different biological specimens, including blood, serum, plasma, hair, meconium, and tissues such as skin surface lipids, sebum, liver and adipose tissue. The FAEEs species used as alcohol biomarkers vary in accordance with the analysed biological specimen, depending on their correlation with alcohol consumption. In this paper, we intend to review the mechanisms of formation and structure of FAEEs to their use as alcohol biomarkers. Focusing on the developed analysis methods, fields of application and published articles, including a critical overview on the methodological challenges and considerations for their analysis; the present limitations and advantages relatively to other alcohol biomarkers; challenges and directions in the research of FAEEs as alcohol biomarkers. © 2018 Nova Science Publishers, Inc. All rights reserved.

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Entidades citadas de la UNAM:

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Fuente:


ISBN:
9781536132076
Editorial:
Nova Science Publishers, Inc. Nombre de la publicación:
Fatty acid ethyl esters as biomarkers of alcohol consumption
Página inicial:
75
Página final:
131

Tipo de producto:
Capítulo de un Libro