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Título del libro: Principles Of Neuro-Oncology: Brain & Skull Base
Título del capítulo: Diagnostic, prognostic and predictive biomarkers in gliomas

Autores UNAM:
TALIA WEGMAN OSTROSKY;
Autores externos:

Idioma:

Año de publicación:
2020
Palabras clave:

Biomarkers; Diagnosis; Gliomas; IDH; MGMT; Molecular biology; Molecular classification; Predictive biomarker; Prognosis biomarker; TP53


Resumen:

In recent years, multiple biomarkers have emerged in the field of neuro-oncology, with useful applications in improving diagnostic accuracy, establishing patient's prognosis and predictive response to available medical therapy. The most frequently associated biomarkers, and their respective alterations, include, IDH1/2 mutation, 1p/19q codeletion, ATRX loss, TP53 mutation, MGMT promoter methylation, BRAF and H3 mutations. In this chapter, we review these biomarkers, but also other less understood ones involved in the diagnosis, prognosis and the treatment of gliomas, such as ABC transporters, AGT mutations, G-CIMP mutation, PTEN mutation, among others. We also include two algorithms for molecular-based decision-making for pediatric and adult gliomas and tables with comprehensive information of biomarkers in gliomas. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2021. All rights reserved.


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