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Título del libro: Immunotherapy In Resistant Cancer: From The Lab Bench Work To Its Clinical Perspectives
Título del capítulo: New intratumoral immunotherapeutic approaches to inhibit the tumor growth and metastasis in breast cancer

Autores UNAM:
JORGE MORALES MONTOR;
Autores externos:

Idioma:

Año de publicación:
2020
Palabras clave:

Breast cancer; Intratumoral immunotherapy; Intratumoral microenvironment; Local delivery; Metastasis; Tumoral growth


Resumen:

Breast cancer presents several unique challenges, in part, because the few tumor antigens that have been identified are expressed in only a relatively small fraction of the tumors. Additionally, the majority of immunotherapeutic approaches have focused on the post-operative setting; nevertheless, strategies that utilize autologous tumor are the most promising of the immunotherapeutic approaches, generating a response against relevant tumor antigens. Even more, benefits of systemic intravenous therapies have been observed only in a small population of patients and have been associated with toxicity profiles. A local intratumoral delivery reduces toxic effects and ensures their arrival. © 2021 Elsevier Inc. All rights reserved.


Entidades citadas de la UNAM: