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Título del libro: Immunotherapy In Resistant Cancer: From The Lab Bench Work To Its Clinical Perspectives
Título del capítulo: Macrophage migration inhibitory factor (MIF): Its role in the genesis and progression of colorectal cancer

Autores UNAM:
IMELDA JUAREZ AVELAR; MARIO ALBERTO TONATHIU RODRIGUEZ HERNANDEZ; MIRIAM RODRIGUEZ SOSA;
Autores externos:

Idioma:

Año de publicación:
2020
Palabras clave:

Cancer; Colorectal cancer; Macrophage migration inhibitory factor; MIF


Resumen:

Macrophage migration inhibitory factor (MIF) is a pleiotropic protein with cytokine and chemokine properties that regulate a diverse range of physiological functions related to innate immunity, inflammation, and glucocorticoid-mediated immunosuppression and is highly expressed by cancer cells, via which it affects angiogenesis, tumor growth, and metastasis. The role of MIF in colorectal cancer (CRC) is underscored by data showing that its overexpression in the chronic stages of CRC is associated with clinical severity. The specific functions of MIF are now being defined in CRC, and MIF-targeted biologic therapeutics are in early-stage trials. In this chapter, we summarize current knowledge about the role of MIF in cancer with special emphasis on CRC. © 2021 Elsevier Inc. All rights reserved.


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