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Título del libro: Vitamin D As Progesterone-Like Hormone: Novel Applications In Obstetrics And Gynecology
Título del capítulo: Vitamin D with alpha-lipoic acid and magnesium for controlling the uterine contractile activity

Autores UNAM:
IMELDA HERNANDEZ MARIN;
Autores externos:

Idioma:

Año de publicación:
2020
Palabras clave:

Alpha lipoic acid and magnesium; Premature delivery; Preterm birth; Uterine activity; Vitamin D


Resumen:

The overall rate of preterm birth is constantly increasing worldwide. In most developed countries, the incidence may range from 5% to 10%. One of the primary symptoms related to preterm birth are premature uterine contractions. Uterine contraction can be treated and/or inhibited with tocolytics drugs. Among them, in obstetrics the most frequently used are oxytocin-receptor antagonists, inhibitors of prostaglandin synthesis, calcium antagonists, nitric oxide (NO) donors, betamimetics and magnesium sulfate. These drugs may present important side effects that should be considered when choosing the right agent. Recently it was shown that oral supplementation with magnesium and lipoic acid reduces the incidence of premature uterine contraction and consequent events of hospitalization. Administration of vitamin D also was shown to reduce the risk of pre-eclampsia, low birthweight and preterm birth. Therefore, it would be useful to better investigate on the combination of natural molecules, such as vitamin D, magnesium and lipoic acid in controlling the uterine contractile activity. © 2020 by Nova Science Publishers, Inc. All rights reserved.


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