Título del libro: Eukaryome Impact On Human Intestine Homeostasis And Mucosal Immunology: Overview Of The First Eukaryome Congress At Institut Pasteur. Paris, October 16-18, 2019.
Título del capítulo: Oxidative Stress and Heat Stress in Experimental Amoebic Liver Abscess
ALFONSO OLIVOS GARCIA; EMMA CECILIA SAAVEDRA LIRA; SERGIO ENRIQUEZ FLORES; MARIO NEQUIZ AVENDAÑO; JULIO CESAR CARRERO SANCHEZ; RUY ALONSO PEREZ TAMAYO;
Autores externos:
Idioma:
Año de publicación:
2020
Palabras clave:
Entamoeba histolytica; Heat shock; Oxidative stress; Pathogenicity
Resumen:
Several species belonging to the Genus Entamoeba can colonize the mouth or the human gut; however, only Entamoeba histolytica is pathogenic to the host, causing amoebiasis. This illness leads to one hundred thousand deaths per year worldwide, affecting mainly underdeveloped countries in areas with poor sanitary conditions. Throughout its life cycle or during the invasion of human tissues, the parasite is constantly subjected to stress conditions. In in vitro culture, this microaerophilic parasite can tolerate up to 50 µM oxygen concentrations; however, during invasion the parasite has to cope with the higher oxygen content found in the blood and well perfused tissues (60?130 µM) and with reactive oxygen and nitrogen species (ROS and NOS, respectively) derived from both the host (as a first line of defense against the infection) and from the oxygen and nitrogen detoxification systems within the parasite. Furthermore, notwithstanding that host body temperatures (36.5?39 °C) observed during amoebic liver infection affect amoebic growth in culture (~50% survival); during tissue invasion the parasite adapts to this stress and proliferates. © Springer Nature Switzerland AG 2020.
Entidades citadas de la UNAM:
ISBN:
9783030448264
Editorial:
Springer International Publishing Nombre de la publicación:
Oxidative Stress and Heat Stress in Experimental Amoebic Liver Abscess
Página inicial:
159
Página final:
169
