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Título del libro: Systemic Lupus Erythematosus: Basic, Applied And Clinical Aspects
Título del capítulo: T Cells

Autores UNAM:
NOE RODRIGUEZ RODRIGUEZ; MARCOS FRANCISCO ROSETTI SCIUTTO;
Autores externos:

Idioma:

Año de publicación:
2016
Palabras clave:

Cytokines; Follicular helper T cells; Gene expression; Regulatory T cells; Systemic lupus erythematosus; T cells; Th17


Resumen:

T cells contribute to the pathogenesis of systemic lupus erythematosus (SLE) as central elements during the loss of tolerance, the perpetuation of the autoimmune response, and by directly instigating inflammation in target organs. Their pathogenic behavior is driven by an abnormal gene expression profile that results from changes in signaling pathways, transcription factor activity, and a grossly altered epigenetic landscape. Here, we describe the signaling and genetic aberrations that make SLE T cells pathogenic and discuss the various mechanisms through which they drive pathology in lupus. © 2016 Elsevier Inc. All rights reserved.


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