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Título del libro: Principles Of Genetics And Molecular Epidemiology
Título del capítulo: Proteomics Principles and Clinical Applications

Autores UNAM:
NADIA ALEJANDRA RIVERO SEGURA;
Autores externos:

Idioma:

Año de publicación:
2022
Palabras clave:

Aging; Cancer and clinical diagnosis; Infectious diseases; Mitochondrial diseases; Neurodegenerative diseases; Proteomics


Resumen:

Proteomics refers to the study of the proteome and the set of proteins present in a cell or organism in health or disease; this comprises a wide variety of techniques, from the 2D-electrophoresis gels to the most advanced technologies such as NMR spectroscopy. Hence, in this chapter we performed a deep review regarding the available proteomic technologies, and the outstanding clinical studies that have used such tools in the quest for useful biomarkers for diagnostic, and for the identification of potential therapeutic targets, including the proteomic profiles displayed in neurodegenerative and mitochondrial-derived diseases, aging and aged-related syndromes, and infectious diseases caused by viruses, bacteria, fungi, and parasites. Finally, this chapter gives a complete overview of the scope of proteomics, since this has proven to be highly sensitive, and specific in a wide range of samples and several diseases, suggesting their potential for being considered in the daily clinical practices. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.


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