Título del libro: Benign Disease Of The Breast: Diagnosis And Treatment
Título del capítulo: Benign breast diseases: Current pathological and molecular concepts
HECTOR AQUILES MALDONADO MARTINEZ; VICTOR DANIEL PEREZ SANCHEZ;
Autores externos:
Idioma:
Inglés
Año de publicación:
2014
Resumen:
BBD of the breast are much more common than malignant lesions. The spectrum of Benign breast disease (BBD) includes a large number of physiopathological lesions of the different components of the breast (epithelial, stromal, adipocytes, or vascular). Breast tissue is under a complex system of influence by systemic factors, particularly hormones, as well as a number of local factors. This interrelationship results in different clinical manifestations for which a clear-cut clinical and histopathological separation between the physiologic and pathologic changes may not be always possible. This situation has led to a great deal of confusion, particularly in certain entities, with different nomenclatures for the same lesion , and unfortunately for many of them, the lack of a unique, unequivocal and commonly accepted definition. In the academic field, the consequence of this situation has been that benign breast disorders have been the subject of a relatively few isolated and unconnected studies, frequently ignoring earlier related work. Hence, it is even more difficult, to find in the literature, complete and broad scope data concerning the mechanisms involved in the development of such disorders. From a practical point of view, much of the interest in BBD focuses on its relationship with the subsequent development of carcinoma. Breast lesions that do not increase the risk of breast cancer should be distinguished from those that confer a small or a moderate increase in risk, and this stratification should be reflected in BBD classification. Taking all of this into account, in this chapter, benign lesions of the breast are summarized to include: inflammatory lesions, fibroepithelial lesions, stromal lesions, benign epithelial proliferations/fibrocystic changes, and benign epithelial neoplasms. Finally, the study of BBD with current molecular methodologies suffers from the same limitations stated previously. However some insight in the biology and classification of BBD has been gained through their application. Such evidence is of importance and is commented on each of the sections of this chapter when available. © 2014 by Nova Science Publishers, Inc. All rights reserved.
Entidades citadas de la UNAM:
ISBN:
9781633216495
Editorial:
Nova Science Publishers, Inc. Nombre de la publicación:
Benign breast diseases: Current pathological and molecular concepts
Página inicial:
249
Página final:
305
Tipo de producto:
Capítulo de un Libro
