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Título del libro: Voltage-Gated Calcium Channels
Título del capítulo: Voltage-Dependent Calcium Channels (CaVs) and CatSper in Spermatogenic and Sperm Cells

Autores UNAM:
ALBERTO DARSZON ISRAEL; IGNACIO LOPEZ GONZALEZ; CLAUDIA LYDIA TREVIÑO SANTA CRUZ;
Autores externos:

Idioma:

Año de publicación:
2022
Palabras clave:

Acrosome reaction; CatSper channels; CatSper regulation; Chemotaxis; Hormonal regulation; Hyperactivation; Mammalian sperm; Rheotaxis; Spermatogenesis; Voltage-dependent Ca2+ channels


Resumen:

As in most cell types, intracellular Ca2+ regulates many fundamental physiological functions in sperm and its progenitors. Ca2+ permeable and voltage-dependent channels in their plasma membrane deeply influence the intracellular Ca2+ concentration. Notably, the role of traditional voltage-dependent Ca2+ channels (CaVs) in spermatogenesis, sperm maturation, motility, and preparation for egg fusion is not well defined. Sperm possesses a unique and very complex Ca2+ channel regulated by intracellular pH, Ca2+, and voltage called CatSper that is key for fertilization and influences motility, and possibly the acrosome reaction (AR). This exocytotic singular event encompasses the fusion of the acrosome vesicle in the posterior region of the head to the plasma membrane preparing this cell to fuse and fertilize the egg. Though CaVs and CatSper may participate in this reaction, it is still a pending question. In this chapter, we examine the characteristics of these Ca2+ channels and their involvement in sperm physiology. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2005, 2022.


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