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Título del libro: Handbook Of Molecular Biotechnology
Título del capítulo: Immuno- and targeted therapies for cancer

Autores UNAM:
RAUL BARRERA RODRIGUEZ;
Autores externos:

Idioma:

Año de publicación:
2024
Resumen:

Cancer is attributed to genetic mutations that induce uncontrolled cell growth and subsequent tumorigenesis. Despite ongoing effects, cancer remains one of the leading causes of death worldwide. As conventional therapy (e.g., surgery, chemotherapy, and radiation) cannot specifically kill cancer cells without harming healthy cells and provide a long-lasting solution to cancer patients, immuno- and targeted therapies have been developed for improved cancer management. Specifically, immunotherapy aims to enhance the immune system's capacity to detect or turn off cancer cells, while targeted therapy utilizes monoclonal antibodies or small drugs to interfere with specific genes or proteins involved in the growth, progression, and spread of cancer cells for ultimate cancer elimination. Although these new therapies have produced some encouraging results to date, there is considerable room for improvement, including elucidating resistance pathways, optimizing patient selection, managing immune-related adverse events, and rationalizing therapeutic combinations. An integrated approach is necessary for identifying additional targets and developing tailored therapy, which will help prolong clinical responses in patients with metastatic cancer and thus drastically transform cancer care. © 2024 selection and editorial matter, Dongyou Liu; individual chapters. All rights reserved.


Entidades citadas de la UNAM: