®®®® SIIA Público

Título del libro: Comprehensive Hematology And Stem Cell Research: Volume 1-5
Título del capítulo: lncRNA-miRNA-mRNA Interaction Networks Regulation in Hematological Malignancies

Autores UNAM:
HERIBERTO PRADO GARCIA; AIDA SUSANA ROMERO GARCIA; ARNOLDO AQUINO GALVEZ;
Autores externos:

Idioma:

Año de publicación:
2024
Palabras clave:

Acute lymphoblastic leukemia (ALL); Acute myeloid leukemia (AML); Chronic lymphocytic leukemia (CLL); Chronic myeloid leukemia (CML); Epigenetic alteration; Hodgkin lymphoma (HL) and non-Hodgkin's lymphoma (NHL); Interaction network (lncrna-mirna-mRNA); Leukemias; Long non-coding RNAs (lncRNAs); microRNAs (miRNAs)


Resumen:

The main hematologic malignancies comprise leukemia, lymphoma, and multiple myeloma, which are liquid cancers originating from blood-forming tissue (immune cells or bone marrow). Characterization of every form of hematological malignancy is of utmost importance for diagnosing, classification, prognosis, and response to treatment evaluation. Although genomic analysis has been crucial for understanding their particular evolution, studying epigenetic regulation, particularly the interaction networks through competitive endogenous RNA mechanisms, is a relatively novel research area. Thus, in the present chapter, we discuss the interaction networks among long non-coding RNAs (lncRNAs), small non-coding RNAs (miRNAs), and mRNAs in leukemias and lymphomas. We summarize the current classification of leukemias and lymphomas and their standard and epigenetic therapies. Studying interaction networks as epigenetic mechanisms will help identify novel biomarkers as potential therapeutic targets for leukemias and lymphomas. © 2024 Elsevier Inc. All rights are reserved.


Entidades citadas de la UNAM: