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Título del libro: Understanding The Pandemic: Pathophysiology, Transmission, And Treatment Of Covid-19
Título del capítulo: Long COVID: Pathophysiological and immunological dynamics

Autores UNAM:
CAROL PERELMAN KHODARI; TALIA WEGMAN OSTROSKY;
Autores externos:

Idioma:

Año de publicación:
2024
Palabras clave:

Classification; Clusters; Immune dysregulation; Inflammation; Long COVID; Mechanisms; Pathophysiology; Viral persistence


Resumen:

Long COVID results from a chronic and multisystemic condition following infection with SARS-CoV-2. Several hypotheses explaining the multiple overlying causes of long COVID have been suggested. However, mechanistic, functional, and clinical studies are in a general early stage to provide clear answers on the pathophysiology of long COVID. To date, most of the classifications of long COVID are based on clinical presentation focusing on the different symptomatology. Further attempts to classify the disease have tried to stratify according to the different pathophysiological mechanisms or clinical clusters. In this chapter, we present some of the main hypotheses and mechanisms proposed to date, which in turn, can overlap in different pathways. In this chapter, we also provide a summary of different studies that have analyzed groups of patients with long COVID to identify patterns with different approaches and propose clusters to classify long COVID. © 2025 Elsevier Inc. All rights are reserved.


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