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Título del libro: Epigenetics In Human Disease, Third Edition
Título del capítulo: Epigenetic programming of human disease and aging

Autores UNAM:
NADIA ALEJANDRA RIVERO SEGURA; JUAN CARLOS GOMEZ VERJAN;
Autores externos:

Idioma:

Año de publicación:
2023
Palabras clave:

Age-related diseases; Cardiac diseases; Cerebral diseases; Epigenetic; Metabolic diseases


Resumen:

As many authors state, aging has been conceptualized as a biological process that leads to declining function and increases the susceptibility to age-related diseases such as cancer, metabolic, cardiovascular, Musculoskeletal, and neurodegenerative diseases. In this context, several efforts have been performed to better understand the complex process that represents aging itself. Currently, epigenetics mechanisms, reversible heritable mechanisms that affect gene expression without underlying changes in the DNA sequences, represent an impactful role in the aging process and concomitantly over age-related diseases. Particularly, DNAm has become a reliable tool to understand the connection among programming aging and disease. Thus, here we aim to bring to the reader a wide perspective about the role of DNAm in both the normal aging process and in the development of the most common age-related diseases, pointing this epigenetic mechanism as a highly relevant biomarker to identify those individuals with higher risk to develop chronic diseases. © 2024 Elsevier Inc. All rights reserved.


Entidades citadas de la UNAM: