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Título del libro: New Drugs Targeting Antibiotic-Resistant Bacteria: Recent Advances
Título del capítulo: Carbapenemases: Impact, Perspectives, and Identification Methods

Autores UNAM:
LUIS ESAU LOPEZ JACOME;
Autores externos:

Idioma:

Año de publicación:
2025
Palabras clave:

Carbapenemase; Carbapenemase classification; Carbapenems; Detection strategy; Global concern; Health concerns; Identification method; Identification tools; Multidrug resistance; Site-specific


Resumen:

© 2025, Bentham Books imprint.Multidrug resistance is a global and severe public health concern; according to data from Jim O´Neil, in 2050, deaths could rise to 10 million. Each time, clinical options are decreasing. The outlook is discouraging, not considering the increased resistance during the COVID-19 pandemic. The last line of defense for clinicians is the use of carbapenems, and developing new clinical pharmacological strategies involves the use of site-specific inhibitors. Identifying the enzymes that degrade these types of antimicrobials is crucial. It is the key to reducing the selection pressure and ensuring their proper use. The half-life of a molecule is dictated by its prescription, and this is where the clinical microbiology laboratory comes in. It is not just a place for testing; it serves as the guiding axis for the correct, adequate, and rational administration of drugs. In this chapter, we will delve into the importance of carbapenemases-mediated resistance and its classification, impact, and detection strategies.


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