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Título del libro: New Drugs Targeting Antibiotic-Resistant Bacteria: Recent Advances
Título del capítulo: Post-antibiotic and Resistance Era

Autores UNAM:
MARIANO MARTINEZ VAZQUEZ;
Autores externos:

Idioma:

Año de publicación:
2025
Palabras clave:

Antibiotics; Bacteria; Bactericides; Candida; Cytotoxicity; Disease control; Halogen compounds; Silver compounds; Bacterial infections; Bactericidal nanoparticle; Bactericidal-drug combination; Carbapenems; CDUUSA; Centres for disease control and preventions; Drug combinations; Drug-resistant bacteria; Hybrid; Quorum-sensing systems; Synthesis (chemical)


Resumen:

The Centers for Disease Control and Prevention (CDC-USA) has categorized bacterial infections as urgent, serious, and concerning threats. In this chapter, we will discuss the antibiotics suggested by the CDC-USA to combat the urgent threats caused by drug-resistant bacteria, including carbapenem-resistant Acinetobacter and Enterobacteriaceae, Candida auris, Clostridioides difficile, and Drug-resistant Neisseria gonorrhoeae. The chapter reviews the efficacy of carbapenem antibiotics when combined with ßlactamase inhibitors. Additionally, it discusses using quorum-sensing inhibitors to prevent virulence factors, focusing on halogen furanone-type compounds. Interestingly, such inhibitors are effective in vitro, but none are currently being evaluated in clinical settings. Finally, some syntheses of nanoparticles to counteract drug-resistant bacteria are reported. Nanoparticles made from metals, especially silver, and those synthesized using biodegradable polymeric materials have shown promising results in cytotoxic activity. However, further studies are needed to determine their effectiveness and toxicity. © 2025, Bentham Books imprint.


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