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Título del libro: Eighteenth Mexican Symposium On Medical Physics
Título del capítulo: Variability of photoplethysmography morphological parameters from peripheral artery disease patients

Autores UNAM:
DAVID HERNANDEZ OBIN; ADRIANA TORRES MACHORRO; CLAUDIA LERMA GONZALEZ;
Autores externos:

Idioma:

Año de publicación:
2025
Resumen:

Peripheral artery disease (PAD) is diagnosed and evaluated by the ankle-brachial index (ABI), an operator-dependent parameter. Photoplethysmography (PPG) is a non-invasive technique that could give complementary physiological information from the analysis of the PPG morphological parameters. In this pilot study, the variability of morphological parameters of PPG signals obtained from 17 legs of 10 patients with peripheral artery disease was analyzed. The morphological parameters include amplitude, pulse transit time (PTT), and mean systolic slope. There were significant differences in the standard deviation (SD) and the high frequency spectral energy (HF) between inter-beat intervals from PPG (PP intervals) and RR intervals. The SD and HF were significantly higher for the PP intervals than for the RR intervals which could represent regulations from different physiological mechanisms or a greater dispersion from the PPG peak detection method. Between PTT obtained from the pulse's foot (PTTf) and PTT obtained from the pulse's peak (PTTp) there were significant differences in the mean and the very low frequency spectral energy (VLF). The mean was greater for PTTp as expected because pulse peak is always after pulse foot. On the other hand, VLF was greater for PTTf which could represent the influence of different regulation mechanisms. Three different methods for pulse foot detection were compared obtaining significant differences in the variability indices computed. The methods used were minimum point method, second derivative method and intersecting tangents method where the intersection tangents was considered as the most consistent method for foot detection. There was no significant correlation between the variability indices and the ABI, although apparent relations are consistent with the literature on PAD effects on the ABI and PPG's morphology.


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