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Título del libro: Neuroscience In Mexico: From Experimental Research To Mental And Neuropsychiatric Health Applications
Título del capítulo: The Advances and Limitations in Autism Research in México: From Experimental Models to Clinical Practice

Autores UNAM:
ELIZABETH GUADALUPE IBARRA CORONADO; PILAR DURAN HERNANDEZ;
Autores externos:

Idioma:

Año de publicación:
2026
Palabras clave:

Animal model; Autism; Autism spectrum disorders; Clinical practices; Clinical research; Communication interaction; Condition; Experimental modelling; Me-xico; Translational neuroscience


Resumen:

© 2026 Nova Science Publishers, Inc.Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by alterations in communication and social interaction, together with restrictive and repetitive patterns of behavior, whose clinical expression is heterogeneous across the life course. Rigorous assessment combines standardized observation and clinical interviews with validated instruments (e.g., DSM-5, ADOS-2, ADI-R, CARS, M-CHAT), enabling comparable phenotypic profiling and informing diagnostic and interventional decision-making. In parallel, animal models, particularly murine models, provide an experimental framework for interrogating synaptic and circuit under controlled conditions. Idiopathic models (BTBR T+ Itpr3tf/J, C58/J) and genetic models (Shank3) capture behavioral and neurobiological domains relevant to ASD. In Mexico, these approaches converge in research lines that integrate behavioral, cellular, and systems neurobiology, as well as clinical initiatives for screening and service organization, thereby fostering a translational bridge between human characterization and preclinical modeling. This article presents a critical synthesis of these fronts, emphasizing their complementarity and the outstanding challenges involved in consolidating reproducible, context-appropriate protocols.


Entidades citadas de la UNAM: