SABINO PACHECO GUILLEN



DATOS GENERALES
Nombre completo   SABINO PACHECO GUILLEN
Máximo nivel de estudios   POSDOCTORADO
Antigüedad académica en la UNAM   9 años
NOMBRAMIENTOS
Vigente   INVESTIGADOR TITULAR A TC No Definitivo
Instituto de Biotecnología
Desde 16-04-2022
INVESTIGADOR ASOCIADO C TC No Definitivo
Instituto de Biotecnología
Desde 16-11-2014 hasta 15-04-2022
POSDOCTOR TC No Definitivo
Instituto de Investigaciones Biomédicas
Desde 11-10-2012 hasta 10-10-2013
ESTIMULOS, PROGRAMAS, PREMIOS Y RECONOCIMIENTOS
* SNI I2016 - VIGENTE
* PRIDE C2020 - VIGENTE
* EQUIVALENCIA PRIDE B2015 - 2019

INFORMACIÓN DE PUBLICACIONES
Firmas  
Pacheco S. Pacheco, S Pacheco, S. Pacheco, Sabino
ID's SCOPUS  
56013563000 23390601200
ORCID's  
0000-0002-0208-0046
Áreas de conocimiento  
Biochemistry & molecular biology Biochemistry and molecular biology Biology Biotechnology and applied microbiology Entomology
Food science and technology Jcs 2008 Materials science, ceramics Microbiology Multidisciplinary sciences
Parasitology Pharmacology & pharmacy Pharmacology and pharmacy Tropical medicine Zoology
Agricultural and Biological Sciences (miscellaneous) Agronomy and Crop Science Applied Microbiology and Biotechnology Biochemistry Biotechnology
Drug Discovery Ecology, evolution, behavior and systematics Endocrinology Food science Insect science
Medicine (miscellaneous) Microbiology (medical) Multidisciplinary Parasitology Pharmacology, toxicology and pharmaceutics (miscellaneous)
Toxicology
Coautorías con entidades de la UNAM  
  • Instituto de Investigaciones Biomédicas
  • Instituto de Biotecnología
  • Facultad de Medicina
  • Escuela Nacional Preparatoria Plantel 3 "Justo Sierra"
  • Coordinación de Estudios de Posgrado
Revistas en las que ha publicado  (22):
  1. ADV INSECT PHYSIOL, Estados Unidos America (2023)
  2. AMB Express, Alemania (2015)
  3. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Estados Unidos America (2017, 2018, 2020, 2021)
  4. Chemotherapy, Suiza (2014)
  5. ENVIRONMENTAL MICROBIOLOGY, Estados Unidos America (2017)
  6. FEBS JOURNAL, Estados Unidos America (2023)
  7. Frontiers In Insect Science, Suiza (2023)
  8. FRONTIERS IN MICROBIOLOGY, Suiza (2016, 2020, 2021)
  9. INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, Reino Unido (2010, 2013, 2018)
  10. JOURNAL OF BIOLOGICAL CHEMISTRY, Estados Unidos America (2009, 2017, 2018, 2020)
  11. JOURNAL OF BIOTECHNOLOGY, Países Bajos (2014)
  12. JOURNAL OF INVERTEBRATE PATHOLOGY, Estados Unidos America (2006)
  13. JOURNAL OF NON-CRYSTALLINE SOLIDS, Países Bajos (2000)
  14. NEW MICROBIOLOGICA, Italia (2017)
  15. Peptides, Estados Unidos America (2008, 2009, 2017)
  16. PLOS NEGLECTED TROPICAL DISEASES, Estados Unidos America (2024)
  17. PLOS ONE, Estados Unidos America (2009, 2013, 2014, 2017)
  18. PLOS PATHOGENS, Estados Unidos America (2021)
  19. PROTEIN ENGINEERING DESIGN & SELECTION, Reino Unido (2014)
  20. SCIENTIFIC REPORTS, Reino Unido (2018)
  21. Southwestern Entomologist, Estados Unidos America (2010)
  22. Toxins, Suiza (2020)


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Documentos indexados (WoS y Scopus)

# Título del documento Autores Año Revista Fuente Citas WoS Citas Scopus
1CRISPR-Cas9 knockout of membrane-bound alkaline phosphatase or cadherin does not confer resistance to Cry toxins in Aedes aegypti1ᵉʳ autor: Pacheco, S, Gallegos, AS, Peláez-Aguilar, AE, Sánchez, J, et al.2024PLOS NEGLECTED TROPICAL DISEASESWoS-id: 001248346000003
Scopus-id: 2-s2.0-85197348859
00
2A major conformational change of N-terminal helices of Bacillus thuringiensis Cry1Ab insecticidal protein is necessary for membrane insertion and toxicity1ᵉʳ autor: Pacheco, Sabino, Gomez, Isabel, Soberon, Mario, Bravo, Alejandra2023FEBS JOURNALWoS-id: 000910920600001
Scopus-id: 2-s2.0-85146180546
67
3Structural changes upon membrane insertion of the insecticidal pore-forming toxins produced by Bacillus thuringiensis1ᵉʳ autor: Pacheco, Sabino, Gomez, Isabel, Pelaez-Aguilar, Angel E., Verduzco-Rosas, Luis A., et al.2023Frontiers In Insect ScienceWoS-id: 001089711600001
Scopus-id: 2-s2.0-85168137536
88
4Mode of action of Bacillus thuringiensis Cry pesticidal proteins2ᵒ autor: Pacheco S., Bravo A., Gómez I., Soberón M.2023ADV INSECT PHYSIOLScopus-id: 2-s2.0-85171686238
010
5Bacillus thuringiensis Cry1Ab Domain III beta-16 Is Involved in Binding to Prohibitin, Which Correlates with Toxicity against Helicoverpa armigera (Lepidoptera: Noctuidae)Coautor: Pacheco, Sabino, Sena da Silva, Igor Henrique, GOMEZ, ISABEL, Sanchez, Jorge, et al.2021APPLIED AND ENVIRONMENTAL MICROBIOLOGYWoS-id: 000605459800008
Scopus-id: 2-s2.0-85099428638
44
6In vivo nanoscale analysis of the dynamic synergistic interaction of Bacillus thuringiensis Cry11Aa and Cyt1Aa toxins in Aedes aegyptiCoautor: Pacheco, Sabino, Lopez-Molina, Samira, do Nascimento, Nathaly Alexandre, Lobo Silva-Filha M.H.N., et al.2021PLOS PATHOGENSWoS-id: 000611973500007
Scopus-id: 2-s2.0-85099803990
1215
7Whole Genome Sequencing Analysis of Bacillus thuringiensis GR007 Reveals Multiple Pesticidal Protein Genes1ᵉʳ autor: Pacheco, Sabino, Gomez, Isabel, Chinas, Marcos, Sanchez, Jorge, et al.2021FRONTIERS IN MICROBIOLOGYWoS-id: 000720147400001
Scopus-id: 2-s2.0-85119412808
109
8Functional Bacillus thuringiensis Cyt1Aa Is Necessary To Synergize Lysinibacillus sphaericus Binary Toxin (Bin) against Bin-Resistant and -Refractory Mosquito SpeciesCoautor: Pacheco, Sabino, Nascimento, Nathaly Alexandre, Torres-Quintero M.C., Molina S.L., et al.2020APPLIED AND ENVIRONMENTAL MICROBIOLOGYWoS-id: 000522978900017
Scopus-id: 2-s2.0-85082093682
1515
9Molecular Characterization of SehB, a Type II Antitoxin of Salmonella enterica Serotype Typhimurium: Amino Acid Residues Involved in DNA-Binding, Homodimerization, Toxin Interaction, and VirulenceCoautor: Pacheco, Sabino, Chimal-Cazares, Fernando, Hernandez-Martinez, Gabriela, Ares, Miguel A., et al.2020FRONTIERS IN MICROBIOLOGYWoS-id: 000529509300001
Scopus-id: 2-s2.0-85083873278
55
10The Cyt1Aa toxin fromBacillus thuringiensisinserts into target membranes via different mechanisms in insects, red blood cells, and lipid liposomes2ᵒ autor: Pacheco, Sabino, Onofre, Janette, Carmen Torres-Quintero, Mary, Gill, Sarjeet S., et al.2020JOURNAL OF BIOLOGICAL CHEMISTRYWoS-id: 000552758600027
Scopus-id: 2-s2.0-85088204248
66
11Rearrangement of N-terminal a-helices of bacillus thuringiensis Cry1Ab toxin essential for oligomer assembly and toxicity1ᵉʳ autor: Pacheco, Sabino, Quiliche J.P.J., Gomez, Isabel, Sanchez, Jorge, et al.2020ToxinsWoS-id: 000586956000001
Scopus-id: 2-s2.0-85092887053
56
12Cell lines as models for the study of Cry toxins from Bacillus thuringiensisCoautor: Pacheco S., Soberón M., Portugal L., Garcia-Gómez B.-I., et al.2018INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGYWoS-id: 000427100600008
Scopus-id: 2-s2.0-85040256066
1417
13Engineering Bacillus thuringiensis Cyt1Aa toxin specificity from dipteran to lepidopteran toxicityCoautor: Pacheco, Sabino, Torres-Quintero, Mary-Carmen, Gomez, Isabel, Sanchez, Jorge, et al.2018SCIENTIFIC REPORTSWoS-id: 000427926500033
Scopus-id: 2-s2.0-85044418520
2528
14Helix alpha-3 inter-molecular salt bridges and conformational changes are essential for toxicity of Bacillus thuringiensis 3D-Cry toxin family1ᵉʳ autor: Pacheco, Sabino, Gomez, Isabel, Sanchez, Jorge, Garcia-Gomez, Blanca-Ines, et al.2018SCIENTIFIC REPORTSWoS-id: 000437830200027
Scopus-id: 2-s2.0-85049876104
1213
15Specific binding between Bacillus thuringiensis Cry9Aa and Vip3Aa toxins synergizes their toxicity against Asiatic rice borer (Chilo suppressalis)Coautor: Pacheco S., Wang Z., Fang L., Zhou Z., et al.2018JOURNAL OF BIOLOGICAL CHEMISTRYWoS-id: 000439449700015
Scopus-id: 2-s2.0-85050393617
3537
16Spodoptera frugiperda (J. E. Smith) aminopeptidase N1 is a functional receptor of the Bacillus thuringiensis Cry1Ca toxinCoautor: Pacheco, Sabino, Gomez, Isabel, Rodriguez-Chamorro, Daniel E., Flores-Ramirez, Gabriela, et al.2018APPLIED AND ENVIRONMENTAL MICROBIOLOGYWoS-id: 000441894000018
Scopus-id: 2-s2.0-85052560284
815
17A single point mutation resulting in cadherin mislocalization underpins resistance against bacillus thuringiensis toxin in cotton bollwormCoautor: Pacheco, Sabino, Xiao, Yutao, Dai, Qing, Hu, Ruqin, et al.2017JOURNAL OF BIOLOGICAL CHEMISTRYWoS-id: 000395535100033
Scopus-id: 2-s2.0-85013380373
3440
18Additional regulatory activities of MrkH for the transcriptional expression of the Klebsiella pneumoniae mrk genes: Antagonist of H-NS and repressorCoautor: Pacheco, Sabino, Ares, Miguel A., Fernandez-Vazquez, Jose L., Martinez-Santos, Veronica I., et al.2017PLOS ONEWoS-id: 000396087900067
Scopus-id: 2-s2.0-85014963676
1214
19The expression of Longus type 4 pilus of enterotoxigenic Escherichia coli is regulated by LngR and LngS and by H-NS, CpxR and CRP global regulatorsCoautor: Pacheco, S., De la Cruz, M.A., Ruiz-Tagle, A., Ares, M.A., et al.2017ENVIRONMENTAL MICROBIOLOGYWoS-id: 000400029800005
Scopus-id: 2-s2.0-85012903249
1313
20The sigma factor SigD of Mycobacterium tuberculosis putatively enhances gene expression of the septum site determining protein under stressful environmentsCoautor: Pacheco S., Ares M.A., Rios-Sarabia N., De La Cruz M.A., et al.2017NEW MICROBIOLOGICAWoS-id: 000411938900009
Scopus-id: 2-s2.0-85029808141
33
21An intramolecular salt bridge in Bacillus thuringiensis Cry4Ba toxin is involved in the stability of helix a-3, which is needed for oligomerization and insecticidal activity1ᵉʳ autor: Pacheco, Sabino, Gomez, Isabel, Sanchez, Jorge, Garcia-Gomez, Blanca-Ines, et al.2017APPLIED AND ENVIRONMENTAL MICROBIOLOGYWoS-id: 000412029400018
Scopus-id: 2-s2.0-85030696964
910
22Identification of Aminopeptidase-N2 as a Cry2Ab binding protein in Manduca sextaCoautor: Pacheco, S., Onofre, J., Gaytán, M.O., Peña-Cardeña, A., et al.2017PeptidesWoS-id: 000417511300013
Scopus-id: 2-s2.0-85009822952
1413
23Transcriptional Profiling of Type II Toxin-Antitoxin Genes of Helicobacter pylori under Different Environmental Conditions: Identification of HP0967-HP0968 SystemCoautor: Pacheco, Sabino, Cardenas-Mondragon, Maria G., Ares, Miguel A., Panunzi, Leonardo G., et al.2016FRONTIERS IN MICROBIOLOGYWoS-id: 000388762100001
Scopus-id: 2-s2.0-85006726043
2021
24Improvement and efficient display of Bacillus thuringiensis toxins on M13 phages and ribosomes1ᵉʳ autor: Pacheco S., Cantón E., ZunigaNavarrete, F, Pecorari F., et al.2015AMB ExpressWoS-id: 000365469300001
Scopus-id: 2-s2.0-84948705759
57
25Potent and specific inhibition of glycosidases by small artificial binding proteins (Affitins)2ᵒ autor: Pacheco S., Correa A., Mechaly A.E., Obal G., et al.2014PLOS ONEWoS-id: 000336369200116
Scopus-id: 2-s2.0-84901281489
3537
26Antibiotic resistance of gram-negative bacilli isolated from pediatric patients with nosocomial bloodstream infections in a Mexican tertiary care hospitalCoautor: Pacheco S., Ares M.A., Alcántar-Curiel M.D., Jiménez-Galicia C., et al.2014ChemotherapyWoS-id: 000336888200008
Scopus-id: 2-s2.0-84899776878
1615
27Affinity transfer to the archaeal extremophilic Sac7d protein by insertion of a CDR1ᵉʳ autor: Pacheco S., Béhar G., Maillasson M., Mouratou B., et al.2014PROTEIN ENGINEERING DESIGN & SELECTIONWoS-id: 000343893400018
Scopus-id: 2-s2.0-84930812168
1315
28Switching an anti-IgG binding site between archaeal extremophilic proteins results in Affitins with enhanced pH stability2ᵒ autor: Pacheco S., Béhar G., Maillasson M., Mouratou B., et al.2014JOURNAL OF BIOTECHNOLOGYWoS-id: 000345970300021
Scopus-id: 2-s2.0-84909582000
1618
29The mitogen-activated protein kinase p38 is involved in insect defense against Cry toxins from Bacillus thuringiensis (vol 40, pg 58, 2010)Coautor: Pacheco, S, Cancino-Rodezno, A, Alexander, C, Villasenor, R, et al.2013INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGYWoS-id: 000323801100012
Scopus-id: 2-s2.0-84881252091
00
30Correction: Dominant negative mutants of Bacillus thuringiensis Cry1Ab toxin function as anti-toxins: Demonstration of the role of oligomerization in toxicity (PLoS ONE)Coautor: Pacheco S., Rodríguez-Almazán C., Zavala L.E., Muñoz-Garay C., et al.2013PLOS ONEScopus-id: 2-s2.0-84896531403
00
31The mitogen-activated protein kinase p38 is involved in insect defense against Cry toxins from Bacillus thuringiensisCoautor: Pacheco S., Cancino-Rodezno A., Alexander C., Villasenor, R, et al.2010INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGYWoS-id: 000275381100007
Scopus-id: 2-s2.0-75949112991
8791
32New Insights into the Mode of Action of Cry1Ab Toxin Used in Transgenic Insect-resistant CropsCoautor: Pacheco, S, Gomez, I, Arenas, I, Bravo, A, et al.2010Southwestern EntomologistWoS-id: 000284301400019
Scopus-id: 2-s2.0-78449271977
22
33Enhancement of insecticidal activity of Bacillus thuringiensis Cry1A toxins by fragments of a toxin-binding cadherin correlates with oligomer formation1ᵉʳ autor: Pacheco S., Gómez I., Gill S.S., Bravo A., et al.2009PeptidesWoS-id: 000264791300019
Scopus-id: 2-s2.0-60749126637
7175
34Dominant Negative Mutants of Bacillus thuringiensis Cry1Ab Toxin Function as Anti-Toxins: Demonstration of the Role of Oligomerization in ToxicityCoautor: Pacheco, S, Rodriguez-Almazan, C, Zavala, LE, Munoz-Garay, C, et al.2009PLOS ONEWoS-id: 000266107300010
Scopus-id: 2-s2.0-65849141019
4448
35Domain II Loop 3 of Bacillus thuringiensis Cry1Ab Toxin Is Involved in a "Ping Pong" Binding Mechanism with Manduca sexta Aminopeptidase-N and Cadherin Receptors1ᵉʳ autor: Pacheco S., Gómez I., Arenas I., Saab-Rincon G., et al.2009JOURNAL OF BIOLOGICAL CHEMISTRYWoS-id: 000272028400060
Scopus-id: 2-s2.0-70450265465
107118
36Employing phage display to study the mode of action of Bacillus thuringiensis Cry toxinsCoautor: Pacheco S., Fernández L.E., Gómez I., Arenas I., et al.2008PeptidesWoS-id: 000253848400022
Scopus-id: 2-s2.0-39149112485
1012
37Functional display of Bacillus thuringiensis Cry1Ac toxin on T7 phage1ᵉʳ autor: Pacheco S., Gómez I., Sato R., Bravo A., et al.2006JOURNAL OF INVERTEBRATE PATHOLOGYWoS-id: 000237712900007
Scopus-id: 2-s2.0-33646154885
1514
38Flocculation process of alumino-silicate particles using different metal ions in aqueous and alcoholic solutions1ᵉʳ autor: Pacheco S., Rodríguez R.2000JOURNAL OF NON-CRYSTALLINE SOLIDSScopus-id: 2-s2.0-0343228764
66
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Documentos no indexados (Humanindex)

# Título del documento ISSN Revista Año Fuente
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Capítulos de libros (WoS y Scopus)

# Título del capítulo Título del libro Autores Alcance Año ISBN Fuente
1Insecticidal proteins from bacillus thuringiensis and their mechanism of actionInsecticidal Proteins From Bacillus Thuringiensis And Their Mechanism Of ActionBravo, A., Pacheco, S., Gómez, I., et al.Capítulo de un Libro20179783319566788WoS-id: 000441179600005
Scopus-id: 2-s2.0-85033995375
2Mechanism of action of Bacillus thuringiensis insecticidal toxins and their use in the control of insect pestsThe Comprehensive Sourcebook Of Bacterial Protein ToxinsBravo, Alejandra, Sanchez, Jorge, Mendoza, Gretel, et al.Article20159780128005897WoS-id: 000462136300031
Scopus-id: 2-s2.0-85054467099
3Countering pest resistance with genetically modified Bt toxinsBt Resistance: Characterization And Strategies For Gm Crops Producing Bacillus Thuringiensis ToxinsSoberón M., García-Gómez B.I., Pacheco S., et al.Capítulo de un Libro20159781780644370WoS-id: 000368988000015
Scopus-id: 2-s2.0-84940639552
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No se encuentran registros en la base de datos de obras con ISBN (Indautor).

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Proyectos

# Nombre Participantes Convocatoria Fecha Inicio Fecha Fin
1Evolución dirigida de toxinas Cry de Bacillus thuringiensis como estrategia para rediseñar el reconocimiento toxina-receptor y contender con la resistencia de plagas agrícolasSABINO PACHECO GUILLEN,
Recursos PAPIIT01-01-201630-03-2018
2Estudio de la arquitectura de poros inducidos por las toxinas Cry1A de Bacillus thuringiensis en membranas utilizando fluorescencia.SABINO PACHECO GUILLEN,
Recursos PAPIIT01-01-201830-12-2019
3Elucidando el papel funcional de múltiples receptores para las toxinas Cry mosquitocidas producidas por Bacillus thuringiensis.SABINO PACHECO GUILLEN,
Recursos CONACYT26-10-202030-06-2023
4Análisis genético/funcional de los trasportadores ABC como moduladores de toxicidad de las proteínas Cry de Bacillus thuringiensis en Aedes aegyptiSABINO PACHECO GUILLEN,
Recursos PAPIIT01-01-202131-12-2023
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Participación en Comités de Tesis

# Título del documento Tipo de Tesis Sinodales Autores Año Entidad Url
1Estandarización de la técnica de ELISA indirecta para el diagnóstico del virus de la Diarrea Epidémica Porcina usando como antígenos el virus completo o mimótopos obtenidos mediante la técnica de Despliegue de FagosTesis de MaestríaSABINO PACHECO GUILLEN; ROSA ELENA SARMIENTO SILVA; MARIA ELENA TRUJILLO ORTEGA; Becerra Hernández, José Francisco; 2019Facultad de Medicina Veterinaria y Zootecnia, Instituto de Biotecnología,
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Docencia Impartida

# Entidad Nivel Asignatura Año Semestre Alumnos
1Instituto de BiotecnologíaMaestríaSEMINARIO DE INVESTIGACIÓN III20212022-11
2Instituto de BiotecnologíaMaestríaTRABAJO DE INVESTIGACIÓN III20212022-11
3Instituto de BiotecnologíaMaestríaTRABAJO DE INVESTIGACIÓN III20212022-11
4Instituto de BiotecnologíaMaestríaSEMINARIO DE INVESTIGACIÓN II20212021-21
5Instituto de BiotecnologíaMaestríaTRABAJO DE INVESTIGACIÓN II20212021-21
6Instituto de BiotecnologíaMaestríaTRABAJO DE INVESTIGACIÓN II20212021-21
7Instituto de BiotecnologíaMaestríaTRABAJO DE INVESTIGACIÓN I20202021-11
8Instituto de BiotecnologíaMaestríaCURSO III20202020-21
9Instituto de BiotecnologíaMaestríaCURSO IV20202020-21
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No se encuentran registros en la base de datos de tutorías impartidas.

No se encuentran registros en la base de datos de reportes técnicos.

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No se encuentran registros en la base de datos de patentes.

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No se encuentran registros en la base de datos de libros completos (Humanindex).

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Capítulos de libros (Humanindex)

# Título del libro Título del capítulo ISBN Editorial Año Fuente