1 | A genomic mutational constraint map using variation in 76,156 human genomes | Coautor: Orozco L., Chen S., Francioli L.C., Goodrich J.K., et al. | 2024 | Nature | WoS-id: 001136836700004 Scopus-id: 2-s2.0-85180828283
| 185 | 196 |
2 | CFTR pathogenic variants spectrum in a cohort of Mexican patients with cystic fibrosis | Coautor: Orozco L., Martínez-Hernández A., Mendoza-Caamal E.C., Mendiola-Vidal N.G., et al. | 2024 | Heliyon | WoS-id: 001226662900001 Scopus-id: 2-s2.0-85189700727
| 0 | 0 |
3 | Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes (Nature, (2024), 625, 7993, (92-100), 10.1038/s41586-023-06045-0) | Coautor: Orozco L., Chen S., Francioli L.C., Goodrich J.K., et al. | 2024 | Nature | Scopus-id: 2-s2.0-85182477492
| 0 | 5 |
4 | The role of single nucleotide variant rs3819817 of the Histidine Ammonia-Lyase gene and 25-Hydroxyvitamin D on bone mineral density, adiposity markers, and skin pigmentation, in Mexican population | Coautor: Orozco, L., Rivera-Paredez, B., Hidalgo-Bravo, A., Leon-Reyes, G., et al. | 2023 | JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | WoS-id: 000942967100002 Scopus-id: 2-s2.0-85149126451
| 2 | 2 |
5 | DNA Methylation Remodeling after Bariatric Surgery Correlates with Clinical Parameters | Coautor: Orozco L., Sánchez E.C., Barajas-Olmos F., Baca P., et al. | 2023 | ADVANCED BIOLOGY | WoS-id: 000981518100001 Scopus-id: 2-s2.0-85158145511
| 0 | 1 |
6 | Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case?control study | 2ᵒ autor: Orozco, Lorena, Berumen, Jaime, Gallardo-Rincon, Hector, Rivas, Fernando, et al. | 2023 | Biology of Sex Differences | WoS-id: 001002768400001 Scopus-id: 2-s2.0-85161387869
| 5 | 7 |
7 | Plasma MicroRNAs Related to Metabolic Syndrome in Mexican Women | Coautor: Orozco L., Ramírez-Solano M.A., Córdova E.J., Tejero M.E. | 2023 | Lifestyle Genomics | WoS-id: 001071439000001 Scopus-id: 2-s2.0-85180539757
| 0 | 0 |
8 | Rare coding variants in 35 genes associate with circulating lipid levels?A multi-ancestry analysis of 170,000 exomes | Coautor: Orozco L., Hindy G., Dornbos P., Chaffin M.D., et al. | 2022 | AMERICAN JOURNAL OF HUMAN GENETICS | WoS-id: 000748493200007 Scopus-id: 2-s2.0-85122004213
| 21 | 21 |
9 | Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation | Coautor: Orozco, Lorena, Mahajan, Anubha, Spracklen, Cassandra N., Zhang, Weihua, et al. | 2022 | NATURE GENETICS | WoS-id: 000794118000004 Scopus-id: 2-s2.0-85130637871
| 242 | 269 |
10 | Exome Sequencing Data Analysis and a Case-Control Study in Mexican Population Reveals Lipid Trait Associations of New and Known Genetic Variants in Dyslipidemia-Associated Loci | Coautor: Orozco, Lorena, Jurado-Camacho, Pedro A., Cid-Soto, Miguel A., Barajas-Olmos, Francisco, et al. | 2022 | Frontiers in Genetics | WoS-id: 000806612000001 Scopus-id: 2-s2.0-85131733069
| 2 | 3 |
11 | Dysferlinopathy misdiagnosed with juvenile polymyositis in the pre-symptomatic stage of hyperCKemia: a case report and literature review | Coautor: Orozco L., Contreras-Cubas C., Barajas-Olmos F., Frayre-Martínez M.I., et al. | 2022 | BMC MEDICAL GENOMICS | WoS-id: 000813791800002 Scopus-id: 2-s2.0-85132255945
| 7 | 7 |
12 | MicroRNA delivery systems in glioma therapy and perspectives: A systematic review | Coautor: Orozco L., Jiménez-Morales J.M., Hernández-Cuenca Y.E., Reyes-Abrahantes A., et al. | 2022 | JOURNAL OF CONTROLLED RELEASE | WoS-id: 000848185500005 Scopus-id: 2-s2.0-85135184184
| 10 | 13 |
13 | A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids | Coautor: Orozco L., Ramdas S., Judd J., Graham S.E., et al. | 2022 | AMERICAN JOURNAL OF HUMAN GENETICS | WoS-id: 000850681500003 Scopus-id: 2-s2.0-85135598739
| 18 | 19 |
14 | A saturated map of common genetic variants associated with human height | Coautor: Orozco, Lorena, Yengo, Loic, Vedantam, Sailaja, Marouli, Eirini, et al. | 2022 | Nature | WoS-id: 000866362700001 Scopus-id: 2-s2.0-85139748621
| 201 | 241 |
15 | Pigmentary mosaicism as a recurrent clinical manifestation in three new patients with mosaic trisomy 12 diagnosed postnatally: cases report and literature review | Coautor: Orozco, L., Martinez-Hernandez, A., Martinez-Anaya, D., Duran-McKinster, C., et al. | 2022 | BMC MEDICAL GENOMICS | WoS-id: 000877014900002 Scopus-id: 2-s2.0-85140943693
| 0 | 0 |
16 | Effect of the Melanocortin 4-Receptor Ile269Asn Mutation on Weight Loss Response to Dietary, Phentermine and Bariatric Surgery Interventions | Coautor: Orozco, Lorena, Salazar-Valencia, Itzel G., Villamil-Ramirez, Hugo, Barajas-Olmos, Francisco, et al. | 2022 | GENES | WoS-id: 000900936600001 Scopus-id: 2-s2.0-85144519990
| 4 | 4 |
17 | DNA methylation and gene expression analysis in adipose tissue to identify new loci associated with T2D development in obesity | Coautor: Orozco, Lorena, Baca, Paulina, Barajas-Olmos, Francisco, Mirzaeicheshmeh, Elaheh, et al. | 2022 | NUTRITION & DIABETES | WoS-id: 000901111200001 Scopus-id: 2-s2.0-85144311204
| 12 | 12 |
18 | Author Correction: Evaluating drug targets through human loss-of-function genetic variation (Nature, (2020), 581, 7809, (459-464), 10.1038/s41586-020-2267-z) | Coautor: Orozco L., Martin H.C., Rhodes D., Trembath R.C., et al. | 2021 | Nature | WoS-id: 000614414900006 Scopus-id: 2-s2.0-85100458973
| 1 | 2 |
19 | Author Correction: The mutational constraint spectrum quantified from variation in 141,456 humans (Nature, (2020), 581, 7809, (434-443), 10.1038/s41586-020-2308-7) | Coautor: Orozco L., Karczewski K.J., Francioli L.C., Tiao G., et al. | 2021 | Nature | WoS-id: 000614414900012 Scopus-id: 2-s2.0-85100468298
| 85 | 45 |
20 | Author Correction: A structural variation reference for medical and population genetics (Nature, (2020), 581, 7809, (444-451), 10.1038/s41586-020-2287-8) | Coautor: Orozco L., Brand H., Zhao X., Francioli L.C., et al. | 2021 | Nature | WoS-id: 000614414900013 Scopus-id: 2-s2.0-85100482354
| 2 | 2 |
21 | Author Correction: Transcript expression-aware annotation improves rare variant interpretation (Nature, (2020), 581, 7809, (452-458), 10.1038/s41586-020-2329-2) | Coautor: Orozco L., Kosmicki J.A., Seaby E.G., Singer-Berk M., et al. | 2021 | Nature | WoS-id: 000614414900014 Scopus-id: 2-s2.0-85100514194
| 0 | 0 |
22 | Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights | Coautor: Orozco, Lorena, Aguilar-Ordonez, Israel, Perez-Villatoro, Fernando, Garcia-Ortiz, Humberto, et al. | 2021 | PLOS ONE | WoS-id: 000639359600024 Scopus-id: 2-s2.0-85104126102
| 9 | 8 |
23 | Clinical and Immunological Factors That Distinguish COVID-19 From Pandemic Influenza A(H1N1) | Coautor: Orozco, Lorena, Choreno-Parra, Jose Alberto, Jimenez-Alvarez, Luis Armando, Cruz-Lagunas, Alfredo, et al. | 2021 | FRONTIERS IN IMMUNOLOGY | WoS-id: 000649459500001 Scopus-id: 2-s2.0-85105932887
| 33 | 38 |
24 | Reconstruction of ancient microbial genomes from the human gut | Coautor: Orozco L., Wibowo M.C., Yang Z., Borry M., et al. | 2021 | Nature | WoS-id: 000650200300003 Scopus-id: 2-s2.0-85105780311
| 124 | 135 |
25 | The L125F MATE1 variant enriched in populations of Amerindian origin is associated with increased plasma levels of metformin and lactate | Coautor: Orozco, Lorena, Morales-Rivera, Monserrat I., Alemon-Medina, Radames, Martinez-Hernandez, Angelica, et al. | 2021 | BIOMEDICINE & PHARMACOTHERAPY | WoS-id: 000700360700001 Scopus-id: 2-s2.0-85112274358
| 3 | 3 |
26 | Alterations of DNA methylation during adipogenesis differentiation of mesenchymal stem cells isolated from adipose tissue of patients with obesity is associated with type 2 diabetes | Coautor: Orozco, Lorena, Mirzaeicheshmeh, Elaheh, ZERRWECK, CARLOS, Centeno-Cruz, Federico, et al. | 2021 | Adipocyte | WoS-id: 000711201500001 Scopus-id: 2-s2.0-85118329024
| 6 | 6 |
27 | The power of genetic diversity in genome-wide association studies of lipids | Coautor: Orozco, Lorena, Graham, Sarah E., Clarke, Shoa L., Wu, Kuan-Han H., et al. | 2021 | Nature | WoS-id: 000728504500001 Scopus-id: 2-s2.0-85121605114
| 360 | 366 |
28 | Replication of integrative data analysis for adipose tissue dysfunction, low-grade inflammation, postprandial responses and omics signatures in symptom-free adults | Coautor: Orozco L., Gallegos-Cabriales E.C., Rodriguez-Ayala E., Laviada-Molina H.A., et al. | 2021 | BIOLOGY-BASEL | WoS-id: 000741496400001 Scopus-id: 2-s2.0-85121581174
| 1 | 1 |
29 | Genetic discovery and risk characterization in type 2 diabetes across diverse populations | Coautor: Orozco, Lorena, Polfus, Linda M., Darst, Burcu F., Highland, Heather, et al. | 2021 | Human Genetics And Genomics Advances | WoS-id: 000787671400008 Scopus-id: 2-s2.0-85111311121
| 29 | 30 |
30 | ALOX5, LPA, MMP9 and TPO gene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans | Coautor: Orozco, Lorena, Camacho-Mejorado, Rafael, Gomez, Rocio, Torres-Sanchez, Luisa E., et al. | 2020 | Royal Society Open Science | WoS-id: 000507382300031 Scopus-id: 2-s2.0-85079638876
| 3 | 3 |
31 | A structural variation reference for medical and population genetics | Coautor: Orozco L., Brand H., Zhao X., Francioli L.C., et al. | 2020 | Nature | WoS-id: 000576060200004 Scopus-id: 2-s2.0-85085567000
| 498 | 516 |
32 | Evaluating drug targets through human loss-of-function genetic variation | Coautor: Orozco L., Martin H.C., Rhodes D., Trembath R.C., et al. | 2020 | Nature | Scopus-id: 2-s2.0-85085564434
| 0 | 100 |
33 | A homozygous CEP57 c.915_925dupCAATGTTCAGC mutation in a patient with mosaic variegated aneuploidy syndrome with rhizomelic shortening in the upper and lower limbs and a narrow thorax | Coautor: Orozco L., De la Torre-García O., Mar-Aldama R., Salgado-Sangri R., et al. | 2019 | EUROPEAN JOURNAL OF MEDICAL GENETICS | WoS-id: 000457638200008 Scopus-id: 2-s2.0-85049879950
| 8 | 7 |
34 | Comparing signals of natural selection between three Indigenous North American populations | Coautor: Orozco L., Reynolds A.W., Mata-Míguez J., Miró-Herrans A., et al. | 2019 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | WoS-id: 000467226400029 Scopus-id: 2-s2.0-85065617714
| 28 | 29 |
35 | Analysis of the dynamic aberrant landscape of DNA methylation and gene expression during arsenic-induced cell transformation | Coautor: Orozco L., Barajas-Olmos F.M., Ortiz-Sánchez E., Imaz-Rosshandler I., et al. | 2019 | Gene | WoS-id: 000479025300011 Scopus-id: 2-s2.0-85068035379
| 11 | 13 |
36 | Associations of autozygosity with a broad range of human phenotypes | Coautor: Orozco, Lorena, Clark, David W., Okada, Yukinori, Moore K.H.S., et al. | 2019 | NATURE COMMUNICATIONS | WoS-id: 000493438700005 Scopus-id: 2-s2.0-85074297784
| 67 | 66 |
37 | Association between APOE polymorphisms and lipid profile in Mexican Amerindian population | Coautor: Orozco L., Martínez-Magaña J.J., Genis-Mendoza A.D., Tovilla-Zarate C.A., et al. | 2019 | Molecular Genetics & Genomic Medicine | WoS-id: 000494745700020 Scopus-id: 2-s2.0-85073922350
| 13 | 17 |
38 | Variation in actionable pharmacogenetic markers in natives and mestizos from Mexico | Coautor: Orozco L., Gonzalez-Covarrubias V., Morales-Franco M., Cruz-Correa O.F., et al. | 2019 | FRONTIERS IN PHARMACOLOGY | WoS-id: 000497523700001 Scopus-id: 2-s2.0-85074210789
| 14 | 14 |
39 | Expression of USP18 and IL2RA Is Increased in Individuals Receiving Latent Tuberculosis Treatment with Isoniazid | Coautor: Orozco L., De Oyarzabal E., García-García L., Rangel-Escareño C., et al. | 2019 | JOURNAL OF IMMUNOLOGY RESEARCH | WoS-id: 000503472400001 Scopus-id: 2-s2.0-85076954841
| 14 | 18 |
40 | Genetic variability of five ADRB2 polymorphisms among Mexican Amerindian ethnicities and the Mestizo population | Coautor: Orozco L., Salas-Martínez M.G., Saldaña-Alvarez Y., Cordova E.J., et al. | 2019 | PLOS ONE | WoS-id: 000533930800022 Scopus-id: 2-s2.0-85075803215
| 4 | 6 |
41 | A homozygous mutation in the PSMB8 gene in a case with proteasome-associated autoinflammatory syndrome | Coautor: Orozco L., Contreras-Cubas C., Cárdenas-Conejo A., Rodríguez-Velasco A., et al. | 2018 | SCANDINAVIAN JOURNAL OF RHEUMATOLOGY | WoS-id: 000432559500013 Scopus-id: 2-s2.0-85029410294
| 3 | 4 |
42 | Influence of SNPs in Genes that Modulate Lung Disease Severity in a Group of Mexican Patients with Cystic Fibrosis | Coautor: Orozco L., Yokoyama E., Chávez-Saldaña M., Cuevas F., et al. | 2018 | Archives Of Medical Research | WoS-id: 000445443700003 Scopus-id: 2-s2.0-85046125919
| 2 | 1 |
43 | GSTT1 and GSTM1 null variants in mestizo and amerindian populations from Northwestern Mexico and a literature review | Coautor: Orozco L., Palma-Cano L.E., Córdova E.J., Martínez-Hernández A., et al. | 2017 | Genetics And Molecular Biology | Scopus-id: 2-s2.0-85035749703
| 0 | 15 |
44 | The NRF2-KEAP1 pathway is an early responsive gene network in arsenic exposed lymphoblastoid cells | Coautor: Orozco L., Córdova E.J., Martínez-Hernández A., Uribe-Figueroa L., et al. | 2014 | PLOS ONE | WoS-id: 000330834400027 Scopus-id: 2-s2.0-84895739598
| 21 | 20 |
45 | Nuclear factor erythroid 2-related factor gene variants and susceptibility of arsenic-related skin lesions | Coautor: Orozco L., Cordova E.J., Valenzuela O.L., Sánchez-Peña L.C., et al. | 2014 | HUMAN & EXPERIMENTAL TOXICOLOGY | WoS-id: 000337597200004 Scopus-id: 2-s2.0-84901386299
| 5 | 5 |
46 | WNT3A gene polymorphisms are associated with bone mineral density variation in postmenopausal mestizo women of an urban Mexican population: Findings of a pathway-based high-density single nucleotide screening | Coautor: Orozco L., Velázquez-Cruz R., García-Ortiz H., Castillejos-López M., et al. | 2014 | AGE | WoS-id: 000342142300039 Scopus-id: 2-s2.0-84905378784
| 29 | 30 |
47 | Molecular screening of the CFTR gene in Mexican patients with congenital absence of the vas deferens | Coautor: Orozco L., Saldaña-Alvarez Y., Jiménez-Morales S., Echevarría-Sánchez M., et al. | 2012 | GENETIC TESTING AND MOLECULAR BIOMARKERS | WoS-id: 000303109400012 Scopus-id: 2-s2.0-84860146377
| 4 | 5 |
48 | HMOX1 promoter (GT)n polymorphism is associated with childhood-onset systemic lupus erythematosus but not with juvenile rheumatoid arthritis in a Mexican population | Coautor: Orozco L., Córdova E.J., Martínez-Hernández A., Ramírez-Bello J., et al. | 2012 | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | WoS-id: 000303905800026 Scopus-id: 2-s2.0-84863732055
| 11 | 11 |
49 | Carrier detection and prenatal molecular diagnosis in a duchenne muscular dystrophy family without any affected relative available | Coautor: Orozco L., Alcántara M.A., García-Cavazos R., Hernández-U E., et al. | 2001 | ANN GENET-PARIS | WoS-id: 000172053300008 Scopus-id: 2-s2.0-0034755465
| 9 | 15 |