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Título del libro: Handbook Of Biologically Active Peptides
Título del capítulo: Adrenomedullin: An Esoteric Juggernaut of Human Cancers

Autores UNAM:
ALFREDO MARTINEZ JIMENEZ;
Autores externos:

Idioma:
Inglés
Año de publicación:
2006
Resumen:

Adrenomedullin (AM) is a pluripotent peptide with diverse biological actions in normal physiology and disease states. It is expressed in both vertebrates and invertebrates. AM is up-regulated in a variety of human malignancies of both neural and epithelial origins, being produced by cancers of the brain, lung, colon, breast, ovary, uterus, prostate, skin, kidney, and eye. It has been found that a patient's serum AM level begins to rise with the onset of lung and gastrointestinal tumor progression. In addition, elevated AM levels in tumor tissue or patient serum indicate a poor clinical prognosis for individuals having prostate or ovarian cancer. Hypoxia and chronic inflammation have been identified as major biological anomalies leading to neoplastic conversion and are also known to be key regulatory pathways responsible for the induction of AM expression. More recently, small molecule inhibitors of AM have been identified that disrupt multiple biological functions of AM and could also be used in the treatment of human cancers. © 2006 Elsevier Inc. All rights reserved.


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