Título del libro: Advances In Psychology Research
Título del capítulo: Evaluation of perinatal and pediatric risk factors for the development of schizophrenia
RAUL ESCAMILLA GUERRERO; ANA FRESAN ORELLANA;
Autores externos:
Idioma:
Inglés
Año de publicación:
2015
Palabras clave:
Early enviromental risk factors; Obstetric complications; Schizophrenia
Resumen:
Background: Schizophrenia is a disorder that affects in a significant degree the psychosocial functioning of the patient in many areas. One of the major risks to have this disorder is related with biological proximity,. although identical twins which share 100% of genetic information do not have a 100% concordance for the development of schizophrenia. Therefore, environmental or epigenetic factors which are not well enough characterized may have a determinant role, during the neurodevelopment phase, on the origin of this disorder. Environmental factors that could affect a liable individual are perinatal, psychosocial and physical and could intervene on early phases of life (i.e., conception, delivery, early maturation). It has been suggested that pediatric and obstetric complications can cause damage which may predispose a susceptible brain for the development of a schizophrenia spectrum disorder. Objectives: To compare pediatric and obstetric complications in patients with schizophrenia and their siblings and to determine which complications are risk factors for the development of schizophrenia. Method: This case-control study explored the association between perinatal risk, pediatric risk neurological conditions (seizures on early infancy, cranial traumatism) and the risk for schizophrenia. A total of 100 patients with schizophrenia diagnosis (SCID- DSM-IV criteria for schizophrenia) and 100 siblings were included. Each case was individually matched by gender and nearly age with one sibling without a psychiatric diagnosis in Axis I (SCID-DSM-IV criteria). Clinical records of the patients were reviewed and a clinical interview with each patient and sibling was performed in addition to an interview with the primary care provider using the following instruments: a) FH-RDC Family History-Research Diagnostic Criteria. b) Lewis-Murray Obstetric Complication Scale. Results: Patients with schizophrenia reported higher rates of head injury and pediatric seizures (>90%). There was a higher prevalence of obstetric/perinatal complications on the group of patients with schizophrenia (47%) compared with their siblings (10%). Patients with schizophrenia exhibited more obstetric complications individually: abnormal length of delivery (p<0.001), umbilical cord prolapse (p<0.03), cardiopulmonary resuscit
Entidades citadas de la UNAM:
ISBN:
9781634823746
Editorial:
Nova Science Publishers, Inc. Nombre de la publicación:
Evaluation of perinatal and pediatric risk factors for the development of schizophrenia
Página inicial:
119
Página final:
139
Tipo de producto:
Capítulo de un Libro
