1 | Inhibition of multidrug-resistant MCF-7 breast cancer cells with combinations of clinical drugs and resin glycosides from Operculina hamiltonii | 2ᵒ autor: Fragoso-Serrano M., Moreno-Velasco A., de Jesús Flores-Tafoya P., Carrillo-Rojas S., et al. | 2024 | Phytochemistry | WoS-id: 001125584500001 Scopus-id: 2-s2.0-85178240746
| 4 | 4 |
2 | Cytotoxicity of Salvigenin from Asterohyptis stellulata in Combination with Clinical Drugs Against Colorectal Cancer | Coautor: Fragoso-Serrano, M, Rojas-Castaño, BA, Hernández-Rojas, AC, Pereda-Miranda, R | 2024 | REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | WoS-id: 001204652800001 Scopus-id: 2-s2.0-85190691999
| 0 | 0 |
3 | Recycling Preparative Liquid Chromatography, the Overlooked Methodology for the Purification of Natural Products | Coautor y autor de correspondencia: Fragoso-Serrano, M, Pereda-Miranda, R, Castañeda-Gómez, JF | 2024 | REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | WoS-id: 001242778100001 Scopus-id: 2-s2.0-85195482779
| 1 | 1 |
4 | Amarissinin F and its 16-epimer, two neo-clerodane diterpenoids from Salvia amarissima containing a 5-hydroxy-furan-2(5H)-one with MDR modulatory activity in cancer cells | 2ᵒ autor: Fragoso-Serrano M., Rojas-Morales J.A., Toscano R.A., Merlín-Lucas V., et al. | 2024 | JOURNAL OF MOLECULAR STRUCTURE | WoS-id: 001284256300001 Scopus-id: 2-s2.0-85197056333
| 0 | 0 |
5 | From Relative to Absolute Stereochemistry of Secondary Metabolites: Applications in Plant Chemistry | Coautor: Fragoso-Serrano M., Pereda-Miranda R., Bautista E., Martínez-Fructuoso L. | 2023 | REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | WoS-id: 000912674200001 Scopus-id: 2-s2.0-85143161088
| 8 | 8 |
6 | In Vitro Assessment of Antiproliferative Activity and Cytotoxicity Modulation of Capsicum chinense By-Product Extracts | Coautor: Fragoso-Serrano M., Chel-Guerrero L.D., Scampicchio M., Ferrentino G., et al. | 2022 | APPLIED SCIENCES-BASEL | WoS-id: 000818230900001 Scopus-id: 2-s2.0-85132183692
| 4 | 4 |
7 | Resin Glycosides from Operculina hamiltonii and Their Synergism with Vinblastine in Cancer Cells | Coautor: Fragoso-Serrano, Mabel, Moreno-Velasco, Armando, Flores-Tafoya, Pedro de Jesu's, Guimaraes Leitao, Suzana, et al. | 2022 | JOURNAL OF NATURAL PRODUCTS | WoS-id: 000862976800001 Scopus-id: 2-s2.0-85139180079
| 10 | 10 |
8 | Jatrophenediol, a pseudoguaiane sesquiterpenoid from Jatropha dioica rhizomes | Coautor: Fragoso-Serrano, Mabel, Bautista, Elihu, Lozano-Gamboa, Sarahi, Rivera-Chavez, Jose, et al. | 2022 | TETRAHEDRON LETTERS | WoS-id: 000864722800025 Scopus-id: 2-s2.0-85135170005
| 2 | 3 |
9 | Amarisolide H and 15-epi-Amarisolide H, Two Diterpenoid Glucosides from Salvia circinnata | 2ᵒ autor: Fragoso-Serrano, Mabel, Garcia-Nava, Xitlalick, Bautista, Elihu, de Loera, Denisse, et al. | 2022 | REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | WoS-id: 000881534100001 Scopus-id: 2-s2.0-85141682439
| 2 | 2 |
10 | Distribution of 5,6-dihydro-alpha-pyrones by electrospray ionization ion trap mass spectrometry in different aerial parts of Hyptis monticola | Coautor: Fragoso-Serrano, Mabel, da Silva, Aline Soares, Martinez-Fructuoso, Lucero, Simas, Rosineide Costa, et al. | 2021 | Phytochemistry | WoS-id: 000639166000009 Scopus-id: 2-s2.0-85101989057
| 4 | 4 |
11 | Glycosidic Acid Content from the Roots of Operculina hamiltonii (Brazilian Jalap) and Some of Their Phytopharmaceuticals with Purgative Activity | Coautor: Fragoso-Serrano M., Montiel-Ayala M.E., Jiménez-Bárcenas N.R., Castañeda-Gómez J., et al. | 2021 | REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | WoS-id: 000725443700003 Scopus-id: 2-s2.0-85120405467
| 5 | 5 |
12 | Dereplication of podophyllotoxin and related cytotoxic lignans in Hyptis verticillata by ultra-high-performance liquid chromatography tandem mass spectrometry | 1ᵉʳ autor: Fragoso-Serrano, Mabel, Pereda-Miranda, Rogelio | 2020 | PHYTOCHEMICAL ANALYSIS | WoS-id: 000477117600001 Scopus-id: 2-s2.0-85076195414
| 4 | 4 |
13 | NMR and SC-XRD analyses of a solid solution of diastereomers of microphyllane diterpenoids from Salvia hirsuta | Coautor: Fragoso-Serrano, Mabel, Toscano, Ruben A., Cardenas, Jorge, Ortiz-Pastrana, Naytze, et al. | 2020 | JOURNAL OF MOLECULAR STRUCTURE | WoS-id: 000504448700040 Scopus-id: 2-s2.0-85075902927
| 4 | 4 |
14 | Salvia connivens, a Source of Bioactive Flavones with Amoebicidal and Giardicidal Activity | Coautor: Fragoso-Serrano, Mabel, Bautista, Elihu, Calzada, Fernando, Yepez-Mulia, Lilian, et al. | 2020 | REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | WoS-id: 000574508200001 Scopus-id: 2-s2.0-85091450502
| 5 | 6 |
15 | Dihydro-furanones from Hyptis species: Chemical correlations and DFT-NMR/ECD calculations for stereochemical assignments | Coautor: Fragoso-Serrano, Mabel, Martinez-Fructuoso, Lucero, Pereda-Miranda, Rogelio, da Silva, Aline Soares, et al. | 2020 | Phytochemistry | WoS-id: 000587366100019 Scopus-id: 2-s2.0-85092006560
| 3 | 3 |
16 | Structure Elucidation, Conformation, and Configuration of Cytotoxic 6-Heptyl-5,6-dihydro-2 H-pyran-2-ones from Hyptis Species and Their Molecular Docking to a-Tubulin | Coautor: Fragoso-Serrano, Mabel, Martinez-Fructuoso, Lucero, Pereda-Miranda, Rogelio, Rosas-Ramirez, Daniel, et al. | 2019 | JOURNAL OF NATURAL PRODUCTS | WoS-id: 000462554100014 Scopus-id: 2-s2.0-85063351795
| 16 | 17 |
17 | Amarisolide F, an Acylated Diterpenoid Glucoside and Related Terpenoids from Salvia amarissima | 1ᵉʳ autor: Fragoso-Serrano, Mabel, Ortiz-Pastrana, Naytze, Luna-Cruz, Norma, Toscano, Ruben A., et al. | 2019 | JOURNAL OF NATURAL PRODUCTS | WoS-id: 000462554100025 Scopus-id: 2-s2.0-85058162944
| 17 | 18 |
18 | Resin Glycosides from the Roots of Operculina macrocarpa (Brazilian Jalap) with Purgative Activity | Coautor: Fragoso-Serrano M., Lira-Ricárdez J., Pereda-Miranda R., Castaneda-Gomez, Jhon, et al. | 2019 | JOURNAL OF NATURAL PRODUCTS | WoS-id: 000473827300032 Scopus-id: 2-s2.0-85067839391
| 13 | 14 |
19 | Acylsugar diversity in the resin glycosides from Ipomoea tricolor seeds as chemosensitizers in breast cancer cells | Coautor: Fragoso-Serrano, Mabel, Castañeda-Gómez J., Lavias-Hernandez, Pedro, Lorence, Argelia, et al. | 2019 | PHYTOCHEMISTRY LETTERS | WoS-id: 000476725000015 Scopus-id: 2-s2.0-85065611031
| 9 | 11 |
20 | Phytochemical Profile, Toxicity, and Pharmacological Potential of Peels from Four Species of Tropical Fruits | Coautor: Fragoso-Serrano M.C., Chel-Guerrero L.D., Sauri-Duch, Enrique, Pérez-Flores L.J., et al. | 2018 | JOURNAL OF MEDICINAL FOOD | WoS-id: 000426116600001 Scopus-id: 2-s2.0-85050272484
| 14 | 15 |
21 | Studies on phytochemical, antioxidant, anti-inflammatory, hypoglycaemic and antiproliferative activities of Echinacea purpurea and Echinacea angustifolia extracts | Coautor: Fragoso-Serrano, Mabel, Clarenc Aarland, Rayn, Ernesto Banuelos-Hernandez, Angel, del Carmen Sierra-Palacios, Edgar, et al. | 2017 | PHARMACEUTICAL BIOLOGY | WoS-id: 000390846600079 Scopus-id: 2-s2.0-85015348142
| 76 | 88 |
22 | Structural elucidation and evaluation of multidrug-resistance modulatory capability of Amarissinins A-C, diterpenes derived from Salvia amarissima (vol 114, pg 1, 2016) | 2ᵒ autor: Fragoso-Serrano, Mabel, Bautista, Elihu, Ortiz-Pastrana, Naytze, Toscano, Ruben A., et al. | 2017 | Fitoterapia | WoS-id: 000392779200022 Scopus-id: 2-s2.0-85006928700
| 0 | 0 |
23 | Complementarity of DFT Calculations, NMR Anisotropy, and ECD for the Configurational Analysis of Brevipolides K-O from Hyptis brevipes | Coautor: Fragoso-Serrano, Mabel, Alejandra Suarez-Ortiz, G., Cerda-Garcia-Rojas, Carlos M., Pereda-Miranda, Rogelio | 2017 | JOURNAL OF NATURAL PRODUCTS | WoS-id: 000393089600024 Scopus-id: 2-s2.0-85011093296
| 28 | 30 |
24 | Resistance-modifying Activity in Vinblastine-resistant Human Breast Cancer Cells by Oligosaccharides Obtained from Mucilage of Chia Seeds (Salvia hispanica) | 2ᵒ autor: Fragoso-Serrano M., Rosas-Ramírez D.G., Escandón-Rivera S., Vargas-Ramírez A.L., et al. | 2017 | PHYTOTHERAPY RESEARCH | WoS-id: 000402958900009 Scopus-id: 2-s2.0-85018615312
| 13 | 18 |
25 | HPLC-MS profiling of the multidrug-resistance modifying resin glycoside content of Ipomoea alba seeds | Coautor: Fragoso-Serrano, Mabel, Castaneda-Gomez, Jhon, Rosas-Ramirez, Daniel, Cruz-Morales, Sara, et al. | 2017 | REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | WoS-id: 000406961700005 Scopus-id: 2-s2.0-85028918520
| 12 | 13 |
26 | Resin glycosides from Ipomoea wolcottiana as modulators of the multidrug resistance phenotype in vitro | Coautor: Fragoso-Serrano, Mabel, Corona-Castaneda, Berenice, Rosas-Ramirez, Daniel, Castaneda-Gomez, Jhon, et al. | 2016 | Phytochemistry | WoS-id: 000371942600006 Scopus-id: 2-s2.0-84957558943
| 17 | 23 |
27 | Conformational and reactivity study of dithiophenyl-fucosyl ketals with theoretical chemical methods | Coautor: Fragoso-Serrano, Mabel, Banuelos-Hernandez, Angel E., Garcia-Gutierrez, Hugo A., Alberto Mendoza-Espinoza, Jose | 2016 | JOURNAL OF MOLECULAR MODELING | WoS-id: 000382748100017 Scopus-id: 2-s2.0-84983608408
| 0 | 1 |
28 | Structural elucidation and evaluation of multidrug-resistance modulatory capability of amarissinins A?C, diterpenes derived from Salvia amarissima | 2ᵒ autor: Fragoso-Serrano, Mabel, Bautista, Elihu, Ortiz-Pastrana, Naytze, Toscano, Ruben A., et al. | 2016 | Fitoterapia | WoS-id: 000386643600001 Scopus-id: 2-s2.0-84982296150
| 24 | 25 |
29 | Jalapinoside II, a bisdesmoside resin glycoside, and related glycosidic acids from the officinal jalap root (Ipomoea purga) | 2ᵒ autor: Fragoso-Serrano, Mabel, Bautista, Elihu, Pereda-Miranda, Rogelio | 2016 | PHYTOCHEMISTRY LETTERS | WoS-id: 000389521400016 Scopus-id: 2-s2.0-84978924461
| 11 | 12 |
30 | Resin Glycosides from Ipomoea alba Seeds as Potential Chemosensitizers in Breast Carcinoma Cells | Coautor: Fragoso-Serrano, Mabel, Cruz-Morales, Sara, Castaneda-Gomez, Jhon, Rosas-Ramirez, Daniel, et al. | 2016 | JOURNAL OF NATURAL PRODUCTS | WoS-id: 000390832700015 Scopus-id: 2-s2.0-85007506832
| 18 | 22 |
31 | Jalapinoside, a macrocyclic bisdesmoside from the resin glycosides of ipomea purga, as a modulator of multidrug resistance in human cancer cells | 2ᵒ autor: FragosoSerrano, M, Bautista, E, PeredaMiranda, R | 2015 | JOURNAL OF NATURAL PRODUCTS | WoS-id: 000348617800023 Scopus-id: 2-s2.0-84921692356
| 24 | 26 |
32 | DFT 1H-1H coupling constants in the conformational analysis and stereoisomeric differentiation of 6-heptenyl-2H-pyran-2-ones: Configurational reassignment of synargentolide a | Coautor: Fragoso-Serrano M., Juárez-González F., Suárez-Ortiz G.A., Cerda-García-Rojas C.M., et al. | 2015 | MAGNETIC RESONANCE IN CHEMISTRY | WoS-id: 000350304600005 Scopus-id: 2-s2.0-84923145081
| 11 | 11 |
33 | Teotihuacanin, a Diterpene with an Unusual Spiro-10/6 System from Salvia amarissima with Potent Modulatory Activity of Multidrug Resistance in Cancer Cells | 2ᵒ autor: FragosoSerrano, M, Bautista, E, Toscano, RA, GarciaPena, MD, et al. | 2015 | ORGANIC LETTERS | WoS-id: 000357623900024 Scopus-id: 2-s2.0-84935049174
| 25 | 30 |
34 | Profiling of brevipolides (5, 6-Dihydro-alpha-Pyrones) in seven colections of Hyptis brevipes (Lamiaceae) | 1ᵉʳ autor: Fragoso-Serrano, M, Pereda-Miranda, R | 2014 | PLANTA MEDICA | WoS-id: 000339781200195
| 0 | 0 |
35 | Hexasaccharide resin glycosides from the jalap roots as modulators of multidrug resistance in MCF-7 cancer cell line | 2ᵒ autor: Fragoso, M, Bautista, E, Pereda-Miranda, R | 2014 | PLANTA MEDICA | WoS-id: 000339781200205
| 0 | 0 |
36 | Modulators of antibiotic activity from Ipomoea murucoides | Coautor: Fragoso-Serrano M., Corona-Castañeda B., Chérigo L., Gibbons S., et al. | 2013 | Phytochemistry | WoS-id: 000326901500023 Scopus-id: 2-s2.0-84893770647
| 16 | 16 |
37 | The opuntia (cactaceae) and dactylopius (hemiptera: Dactylopiidae) in mexico: A historical perspective of use, interaction and distribution with particular emphasis on chemical and phylogenetic aspects of the dactylopius species | Coautor: Fragoso-Serrano M., Chávez-Moreno C.K., Tecante A., Rogelio P.-M., et al. | 2013 | Acta Horticulturae | WoS-id: 000332553000048 Scopus-id: 2-s2.0-84880179435
| 0 | 0 |
38 | Resin Glycosides of Ipomoea alba Seeds as Mammalian Resistance Modifying Agents | 1ᵉʳ autor: Fragoso-Serrano, M, Morales, SC, Figueroa-Gonzalez, G, Pereda-Miranda, R | 2013 | PLANTA MEDICA | WoS-id: 000338695100104
| 0 | 0 |
39 | Profiling of Alkaloids and Eremophilanes in Miracle Tea (Packera candidissima and P. bellidifolia) Products | 1ᵉʳ autor: Fragoso-Serrano, M, Figueroa-Gonzalez, G, Castro-Carranza, E, Hernandez-Solis, F, et al. | 2012 | JOURNAL OF NATURAL PRODUCTS | WoS-id: 000304385800007 Scopus-id: 2-s2.0-84861553152
| 9 | 9 |
40 | Profiling of Alkaloids and Eremophilanes in Miracle Tea (Packera candidissima and P. bellidifolia) Products | 1ᵉʳ autor: Fragoso-Serrano, M, Figueroa-Gonzalez, G, Pereda-Miranda, R | 2012 | PLANTA MEDICA | WoS-id: 000307042801095
| 0 | 0 |
41 | Vicinal H-1-H-1 NMR Coupling Constants from Density Functional Theory as Reliable Tools for Stereochemical Analysis of Highly Flexible Multichiral Center Molecules | 2ᵒ autor: Fragoso-Serrano M., López-Vallejo F., Suárez-Ortiz G.A., Hernández-Rojas A.C., et al. | 2011 | JOURNAL OF ORGANIC CHEMISTRY | WoS-id: 000293252600019 Scopus-id: 2-s2.0-79961088170
| 25 | 25 |
42 | Characterization of a xylose containing oligosaccharide, an inhibitor of multidrug resistance in Staphylococcus aureus, from Ipomoea pes-caprae | Coautor: Fragoso-Serrano M., Escobedo-Martínez C., Cruz-Morales S., Rahman, MM, et al. | 2010 | Phytochemistry | WoS-id: 000282453900024 Scopus-id: 2-s2.0-77956340961
| 32 | 37 |
43 | Metabolic profiling of Dactylopius (Hemiptera Dactylopiidae) species pigments by geographical origin and hosts using multivariate data analysis | Coautor: Fragoso-Serrano, M, Chavez-Moreno, CK, Tecante, A, Pereda-Miranda, R | 2010 | BIOCHEMICAL SYSTEMATICS AND ECOLOGY | WoS-id: 000284565800027 Scopus-id: 2-s2.0-77958470917
| 11 | 10 |
44 | Structural Reassignment, Absolute Configuration, and Conformation of Hypurticin, a Highly Flexible Polyacyloxy-6-heptenyl-5,6-dihydro-2H-pyran-2-one | Coautor: Fragoso-Serrano M., Mendoza-Espinoza J.A., López-Vallejo F., Pereda-Miranda R., et al. | 2009 | JOURNAL OF NATURAL PRODUCTS | WoS-id: 000265530000019 Scopus-id: 2-s2.0-65649117433
| 35 | 38 |
45 | Inhibitors of bacterial multidrug efflux pumps from the resin glycosides of Ipomoea murucoides | Coautor: Fragoso-Serrano M., Chérigo L., Pereda-Miranda R., Jacobo-Herrera N., et al. | 2008 | JOURNAL OF NATURAL PRODUCTS | WoS-id: 000257227200021 Scopus-id: 2-s2.0-47649123856
| 69 | 79 |
46 | Calcium-dependent effect of Tricolorin A on intestinal and arterial smooth muscle contractility | Coautor: Fragoso, M, Hernandez, R, Vuelvas, A, Garcia, A, et al. | 2008 | PLANTA MEDICA | WoS-id: 000258261800294
| 5 | 0 |
47 | Inhibitors of bacterial multidrug efflux pumps from the resin glycosides of Ipomoea species | Coautor: Fragoso-Serrano, M, Pereda-Miranda, R, Cherigo, L, Jacobo-Herrera, N, et al. | 2008 | PLANTA MEDICA | WoS-id: 000258261801015
| 0 | 0 |
48 | Intrapilosins I-VII, pentasaccharides from the seeds of Ipomoea intrapilosa | Coautor: Fragoso-Serrano M., Bah M., Chérigo L., Cardoso Taketa A.T., et al. | 2007 | JOURNAL OF NATURAL PRODUCTS | WoS-id: 000248344800016 Scopus-id: 2-s2.0-34548026760
| 23 | 23 |
49 | Profiling of the resin glycoside content of Mexican Jalap roots with purgative activity | 2ᵒ autor: Fragoso-Serrano M., Pereda-Miranda R., Escalante-Sánchez E., Hernández-Carlos B., et al. | 2006 | JOURNAL OF NATURAL PRODUCTS | WoS-id: 000241562700017 Scopus-id: 2-s2.0-33845474326
| 44 | 46 |
50 | Density functional theory calculations and experimental parameters for mutarotation of 6-deoxy-l-mannopyranosyl hydrazine | 1ᵉʳ autor: Fragoso-Serrano M., Pereda-Miranda R., Cerda-García-Rojas C.M. | 2006 | Tetrahedron | WoS-id: 000242483100007 Scopus-id: 2-s2.0-33751200991
| 7 | 7 |
51 | Anti-staphylococcal and cytotoxic compounds from Hyptis pectinata | 1ᵉʳ autor: Fragoso-Serrano M., Gibbons S., Pereda-Miranda R. | 2005 | PLANTA MEDICA | WoS-id: 000227912500016 Scopus-id: 2-s2.0-16444369792
| 38 | 43 |
52 | Isolation of Nor-secofriedelanes from the Sedative Extracts of Galphimia glauca | Coautor: Fragoso-Serrano M., Cardoso Taketa A.T., Lozada-Lechuga J., Villarreal M.L., et al. | 2004 | JOURNAL OF NATURAL PRODUCTS | WoS-id: 000221001000018 Scopus-id: 2-s2.0-2042500486
| 33 | 31 |
53 | Stereoselective synthesis and determination of the cytotoxic properties of spicigerolide and three of its stereoisomers | Coautor: Fragoso-Serrano M., Falomir E., Murga J., Ruiz P., et al. | 2003 | JOURNAL OF ORGANIC CHEMISTRY | WoS-id: 000184060600028 Scopus-id: 2-s2.0-0037662050
| 40 | 43 |
54 | Conformational analysis of sulfur-containing 6-deoxy-L-hexose derivatives by molecular modeling and NMR spectroscopy. A theoretical study and experimental evidence of intramolecular nonbonded interactions between sulfur and oxygen | 1ᵉʳ autor: Fragoso-Serrano M., Guillén-Jaramillo G., Pereda-Miranda R., Cerda-García-Rojas C.M. | 2003 | JOURNAL OF ORGANIC CHEMISTRY | WoS-id: 000185343200003 Scopus-id: 2-s2.0-0141789945
| 8 | 8 |
55 | Application of molecular mechanics in the total stereochemical elucidation of spicigerolide, a cytotoxic 6-tetraacetyl-oxyheptenyl-5,6-dihydro-a-pyrone from Hyptis spicigera | 2ᵒ autor: Fragoso-Serrano M., Pereda-Miranda R., Cerda-García-Rojas C.M. | 2001 | Tetrahedron | WoS-id: 000166224300004 Scopus-id: 2-s2.0-0035057016
| 87 | 86 |
56 | Novel labdane diterpenes from the insecticidal plant Hyptis spicigera | 1ᵉʳ autor: Fragoso-Serrano M., González-Chimeo E., Pereda-Miranda R. | 1999 | JOURNAL OF NATURAL PRODUCTS | WoS-id: 000078186300007 Scopus-id: 2-s2.0-0345654335
| 25 | 27 |
57 | Stereoselective tandem Michael-intramolecular cyclization approach to functionalized pyrroloisoindolones | Coautor: Fragoso M.C., Reyes A., Regla I., Vallejo L.A., et al. | 1999 | Tetrahedron | WoS-id: 000082283600003 Scopus-id: 2-s2.0-0033543472
| 10 | 9 |